Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.50 |
| ▸ | DHX9 | Q08211 | 1/20 | 0.49 |
| ▸ | KDM1A | O60341 | 2/20 | 0.48 |
| ▸ | RCOR1 | Q9UKL0 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | GRN | P28799 | 1/20 | 0.41 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21652915 | 0.80 | CREBBP (0.55) | LMNAALDH1A1MAPTCYP2C19NPC1 | |
| SCHEMBL21653182 | 0.77 | KMT2A (0.52) | LMNAMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL21653121 | 0.77 | RAB9A (0.53) | LMNAALDH1A1ROCK1SMN1; SMN2HPGD | |
| SCHEMBL21652920 | 0.77 | MAPT (0.42) | MAPTCYP2C19NPC1RAB9ARPS6KA2 | |
| SCHEMBL21653177 | 0.76 | MAPT (0.46) | ALDH1A1MAPTCYP2C19NPSR1SMN1; SMN2 | |
| SCHEMBL21653246 | 0.76 | MAPT (0.43) | ALDH1A1MAPTCYP2C19SMN1; SMN2NPC1 | |
| SCHEMBL30216595 | 0.75 | SMN1; SMN2 (0.64) | LMNAALDH1A1MAPTROCK1DHX9 | |
| SCHEMBL374330 | 0.75 | DHX9 (0.65) | LMNAALDH1A1MAPTROCK1DHX9 | |
| SCHEMBL21653108 | 0.74 | CA9 (0.43) | LMNAALDH1A1MAPTCYP2C19NPC1 | |
| SCHEMBL21653176 | 0.74 | MEN1 (0.58) | LMNAMAPTNPSR1SMN1; SMN2MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020023657-A1 | PYRIDIN-2-ONE COMPOUNDS USEFUL AS SMARCA2 ANTAGONISTS | Epizyme, Inc. (US) | 2020-01-30 | — | — | WO | disclosed |