Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 12/20 | 0.43 |
| ▸ | CNR1 | P21554 | 8/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.38 |
| ▸ | MME | P08473 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21653197 | 0.79 | RAB9A (0.55) | ALDH1A1KDM4E | |
| SCHEMBL21653203 | 0.79 | SMN1; SMN2 (0.46) | ALDH1A1KDM4ECYP3A4CYP2C9CYP2C19 | |
| SCHEMBL21653300 | 0.78 | PTPN1 (0.54) | ALDH1A1KDM4E | |
| SCHEMBL21652982 | 0.77 | ALDH1A1 (0.46) | CNR2CNR1ALDH1A1KDM4EACKR3 | |
| SCHEMBL21653188 | 0.76 | NAMPT (0.42) | ALDH1A1KDM4ECYP3A4CYP2C9CYP2C19 | |
| SCHEMBL21653191 | 0.75 | NAMPT (0.41) | ALDH1A1KDM4ECYP3A4CYP2C9CYP2C19 | |
| SCHEMBL21653189 | 0.74 | RAB9A (0.43) | ALDH1A1KDM4ECYP3A4CYP2C9CYP2C19 | |
| SCHEMBL21652915 | 0.73 | CREBBP (0.55) | ALDH1A1KDM4ECYP3A4CYP2C9CYP2C19 | |
| SCHEMBL21653295 | 0.73 | PFKFB3 (0.55) | — | |
| SCHEMBL21653182 | 0.70 | KMT2A (0.52) | KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020023657-A1 | PYRIDIN-2-ONE COMPOUNDS USEFUL AS SMARCA2 ANTAGONISTS | Epizyme, Inc. (US) | 2020-01-30 | — | — | WO | disclosed |