Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 4/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16507870 | 0.74 | TAAR1 (0.54) | CYP19A1TAAR1GFERPTGS1PTGS2 | |
| SCHEMBL19877367 | 0.74 | LOXL2 (0.51) | — | |
| SCHEMBL20960412 | 0.70 | TDP1 (0.42) | CYP19A1 | |
| SCHEMBL22504236 | 0.68 | TAAR1 (0.46) | CYP19A1TAAR1GFERPTGS1PTGS2 | |
| SCHEMBL9979794 | 0.68 | AOC3 (0.34) | — | |
| SCHEMBL24336328 | 0.67 | ALDH1A1 (0.33) | — | |
| SCHEMBL24557304 | 0.67 | TDP1 (0.47) | TAAR1 | |
| SCHEMBL6206391 | 0.66 | AOC3 (0.44) | — | |
| SCHEMBL10917544 | 0.66 | CES2 (0.46) | PTGS2 | |
| SCHEMBL18697179 | 0.65 | PDE2A (0.35) | PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10934280-B2 | Condensed thiophene derivatives useful as NaPi-IIb inhibitors | ELI LILLY AND COMPANY (US) | 2021-03-02 | — | — | US | disclosed |
| US-20200031813-A1 | CONDENSED THIOPHENE DERIVATIVES USEFUL AS NAPI-IIB INHIBITORS | ELI LILLY AND COMPANY | 2020-01-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10934280-B2 | Condensed thiophene derivatives useful as NaPi-IIb inhibitors | SLC34A2, ALPI, SLC34A1 | CYP19A1 3394/4885TAAR1 529/4885GFER 3168/4885 |
| US-20200031813-A1 | CONDENSED THIOPHENE DERIVATIVES USEFUL AS NAPI-IIB INHIBITORS | SLC34A2, ALPI, SLC34A1 | CYP19A1 3394/4885TAAR1 529/4885GFER 3168/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.