Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 2/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | HTR2C | P28335 | 2/20 | 0.44 |
| ▸ | HTR2B | P41595 | 2/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 6/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6560519 | 0.88 | GABRA1 (0.42) | HTR2ASLC6A2 | |
| SCHEMBL20207667 | 0.81 | NOS3 (0.52) | SLC6A2CYP2A6 | |
| SCHEMBL21686484 | 0.78 | KDM4E (0.41) | — | |
| SCHEMBL15911399 | 0.78 | PNMT (0.46) | PNMTHTR2AHTR2CHTR2BTAAR1 | |
| SCHEMBL23153071 | 0.77 | NOS3 (0.43) | — | |
| SCHEMBL17000195 | 0.77 | POLB (0.44) | SLC6A2 | |
| SCHEMBL27209025 | 0.76 | LNPEP (0.34) | SLC6A2 | |
| SCHEMBL30846842 | 0.76 | LNPEP (0.34) | SLC6A2 | |
| SCHEMBL19822051 | 0.76 | LNPEP (0.37) | SLC6A2 | |
| SCHEMBL14468360 | 0.76 | GABRA1 (0.39) | SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3010910-B1 | PYRIMIDINEDIONE COMPOUNDS AGAINST CARDIAC CONDITIONS | MYOKARDIA INC (US) | 2020-02-05 | — | — | EP | disclosed |