Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | CTSS | P25774 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6560519 | 0.86 | GABRA1 (0.42) | GABRA1GABRB2KDM4EPOLBSMN1; SMN2 | |
| SCHEMBL17000195 | 0.82 | POLB (0.44) | GABRA1GABRB2KDM4EPOLBSMN1; SMN2 | |
| SCHEMBL23863910 | 0.81 | GABRA1 (0.39) | GABRA1GABRB2KDM4EPOLBSMN1; SMN2 | |
| SCHEMBL17000197 | 0.79 | KDM4E (0.49) | GABRA1GABRB2KDM4ELNPEPCTSS | |
| SCHEMBL18458630 | 0.78 | GABRA1 (0.48) | GABRA1GABRB2KDM4EPOLBSMN1; SMN2 | |
| SCHEMBL18924479 | 0.78 | ESR1 (0.43) | SMN1; SMN2PGRADORA3PTGS1SLC6A2 | |
| SCHEMBL19822050 | 0.78 | PGR (0.40) | GABRA1GABRB2KDM4EPOLBSMN1; SMN2 | |
| SCHEMBL14470239 | 0.78 | NOS3 (0.55) | KDM4EPOLBNOS3NOS1NOS2 | |
| SCHEMBL487712 | 0.76 | UHRF1 (0.46) | GABRA1GABRB2KDM4EPOLBSMN1; SMN2 | |
| SCHEMBL21667315 | 0.76 | PNMT (0.46) | SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070155737-A1 | Heterobicyclic metalloprotease inhibitors | ALANTOS PHARMACEUTICALS, INC. | 2007-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070155737-A1 | Heterobicyclic metalloprotease inhibitors | ADAMTS4, ADAMTS1, ADAMTS5 | GABRA1 2177/4885GABRB2 1169/4885KDM4E 418/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.