Sugi Predict

Sugi Predict / Compounds / SCHEMBL21671283

SCHEMBL21671283

SCHEMBL21671283

N[C@@H](COc1ccccc1Cl)C(=O)O

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CYP1A2 P05177 1/20 0.51
▸ GAA P10253 1/20 0.51
▸ CYP2C19 P33261 1/20 0.51
▸ TDP1 Q9NUW8 1/20 0.51
▸ SLC1A5 Q15758 2/20 0.49
▸ HPGD P15428 3/20 0.49
▸ HTT P42858 2/20 0.49
▸ TP53 P04637 2/20 0.49
▸ RXRA P19793 1/20 0.49
▸ RXRB P28702 1/20 0.49
▸ MEN1 O00255 5/20 0.48
▸ KMT2A Q03164 5/20 0.48
▸ USP2 O75604 1/20 0.48
▸ PKM P14618 2/20 0.47
▸ RAB9A P51151 3/20 0.47
▸ POLB P06746 1/20 0.47
▸ HDAC6 Q9UBN7 1/20 0.46
▸ NPC1 O15118 1/20 0.46
▸ MITF O75030 1/20 0.46
▸ XBP1 P17861 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21837903 1.00 CYP1A2 (0.51) CYP1A2GAACYP2C19TDP1SLC1A5
SCHEMBL5080191 0.84 SLC1A5 (0.53) SLC1A5HPGDHTTTP53RXRA
SCHEMBL5607010 0.84 SLC1A5 (0.53) SLC1A5HPGDHTTTP53RXRA
SCHEMBL21837419 0.83 HPGD (0.48) CYP1A2GAACYP2C19TDP1HPGD
SCHEMBL30861876 0.83 HPGD (0.48) CYP1A2GAACYP2C19TDP1HPGD
SCHEMBL21837420 0.83 HPGD (0.48) CYP1A2GAACYP2C19TDP1HPGD
SCHEMBL16501758 0.81 CYP1A2 (0.44) CYP1A2GAACYP2C19TDP1HPGD
SCHEMBL22737054 0.81 KYNU (0.47) CYP1A2CYP2C19SLC1A5PKMALPI
SCHEMBL28430552 0.80 LMNA (0.59) CYP1A2SLC1A5RXRAKMT2APOLB
SCHEMBL21895849 0.80 MEN1 (0.54) CYP1A2GAACYP2C19TDP1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119080856-A Mutant tRNA for codon extension 中外制药株式会社 2024-12-06 — — CN disclosed
CN-113423877-B Mutant tRNA for codon extension 中外制药株式会社 2024-09-13 — — CN disclosed
CN-118256591-A Cyclic peptide compound having high membrane permeability and library comprising same 中外制药株式会社 2024-06-28 — — CN disclosed
CN-110869544-B Cyclic peptide compound having high membrane permeability and library comprising same 中外制药株式会社 2024-03-08 — — CN disclosed
US-20240052340-A1 TRANSLATION SYSTEM PROVIDED WITH MODIFIED GENETIC CODE TABLE CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2024-02-15 — — US disclosed
EP-4166675-A1 TRANSLATION SYSTEM PROVIDED WITH MODIFIED GENETIC CODE TABLE CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2023-04-19 — — EP disclosed
US-20230108274-A1 COMPOSITION FOR TRANSLATION, AND METHOD FOR PRODUCING PEPTIDE CHUGAI PHARMACEUTICAL CO LTD (JP) 2023-04-06 — — US disclosed
CN-115667539-A Translation system with altered genetic code tables 中外制药株式会社 2023-01-31 — — CN disclosed
EP-4026906-A1 COMPOSITION FOR TRANSLATION, AND METHOD FOR PRODUCING PEPTIDE CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2022-07-13 — — EP disclosed
US-20220205009-A1 MUTATED tRNA FOR CODON EXPANSION CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2022-06-30 — — US disclosed
EP-3904568-A1 MUTATED TRNA FOR CODON EXPANSION CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2021-11-03 — — EP disclosed
CN-113423877-A Mutant tRNAs for codon expansion 中外制药株式会社 2021-09-21 — — CN disclosed
WO-2021132546-A1 COMPOSITION FOR TRANSLATION, AND METHOD FOR PRODUCING PEPTIDE 中外製薬株式会社 2021-07-01 — — WO disclosed
WO-2020138336-A1 MUTATED TRNA FOR CODON EXPANSION 中外製薬株式会社 2020-07-02 — — WO disclosed
US-20200131669-A1 CYCLIC PEPTIDE COMPOUND HAVING HIGH MEMBRANE PERMEABILITY, AND LIBRARY CONTAINING SAME CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2020-04-30 — — US disclosed
US-20200131669-A1 CYCLIC PEPTIDE COMPOUND HAVING HIGH MEMBRANE PERMEABILITY, AND LIBRARY CONTAINING SAME CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2020-04-30 — — US disclosed
EP-3636807-A1 CYCLIC PEPTIDE COMPOUND HAVING HIGH MEMBRANE PERMEABILITY, AND LIBRARY CONTAINING SAME Chugai Seiyaku Kabushiki Kaisha (JP) 2020-04-15 — — EP disclosed
EP-3636807-A1 CYCLIC PEPTIDE COMPOUND HAVING HIGH MEMBRANE PERMEABILITY, AND LIBRARY CONTAINING SAME Chugai Seiyaku Kabushiki Kaisha (JP) 2020-04-15 — — EP disclosed
CN-110869544-A Cyclic peptide compound having high membrane permeability and library containing same 中外制药株式会社 2020-03-06 — — CN disclosed
US-20200040372-A1 METHOD FOR SYNTHESIZING PEPTIDES IN CELL-FREE TRANSLATION SYSTEM CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2020-02-06 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200040372-A1 METHOD FOR SYNTHESIZING PEPTIDES IN CELL-FREE TRANSLATION SYSTEM AARS1, NSUN3, RNGTT CYP1A2 4828/4885GAA 1742/4885CYP2C19 4780/4885
US-20200131669-A1 CYCLIC PEPTIDE COMPOUND HAVING HIGH MEMBRANE PERMEABILITY, AND LIBRARY CONTAINING SAME VIP, SLC7A1, TRPV1 CYP1A2 3607/4885GAA 3176/4885CYP2C19 1377/4885
US-20230108274-A1 COMPOSITION FOR TRANSLATION, AND METHOD FOR PRODUCING PEPTIDE NSUN3, TARBP1, NOP2 CYP1A2 4789/4885GAA 2905/4885CYP2C19 4027/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.