Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 3/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 3/20 | 0.44 |
| ▸ | THRA | P10827 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.41 |
| ▸ | MMP14 | P50281 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17899401 | 0.87 | SLC6A2 (0.41) | PARP10SLC6A2SLC6A4MAOBMAPK1 | |
| SCHEMBL3017507 | 0.78 | PARP10 (0.71) | PARP10THRAMAPTMMP14L3MBTL1 | |
| SCHEMBL17899375 | 0.78 | CHEK2 (0.39) | PARP10SLC6A2SLC6A4MAOBMAPT | |
| SCHEMBL21697477 | 0.78 | PARP10 (0.54) | PARP10SLC6A2SLC6A4MAOBMAPT | |
| SCHEMBL3014872 | 0.77 | PARP10 (0.69) | PARP10THRAMAPTMMP14L3MBTL1 | |
| SCHEMBL17899369 | 0.72 | SLC6A2 (0.38) | PARP10SLC6A2SLC6A4MAPTKDM4E | |
| SCHEMBL6135839 | 0.71 | THRA (0.49) | SLC6A2SLC6A4MAOBTHRAMAPK1 | |
| SCHEMBL10352175 | 0.71 | NCF1 (0.50) | THRAMAPK1MAPTKDM4ELMNA | |
| SCHEMBL6302583 | 0.71 | KMT2A (0.60) | PARP10MAPK1MAPTKDM4ELMNA | |
| SCHEMBL3649917 | 0.70 | PARP10 (0.58) | PARP10SLC6A2SLC6A4MAOBMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3607944-A1 | NOVEL CYCLIN-DEPENDENT KINASE 8 AND/OR 19 INHIBITOR | Kyoto Pharmaceutical Industries, Ltd. (JP) | 2020-02-12 | — | — | EP | disclosed |