Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | REV1 | Q9UBZ9 | 2/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA7 | P43166 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.46 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2171705 | 0.95 | MEN1 (0.60) | LMNAMEN1KMT2AALDH1A1REV1 | |
| SCHEMBL2170811 | 0.95 | MAPT (0.54) | LMNAMEN1KMT2AALDH1A1REV1 | |
| SCHEMBL2171096 | 0.89 | SCN9A (0.51) | MEN1KMT2AALDH1A1SCN9APOLB | |
| SCHEMBL2171851 | 0.89 | KMT2A (0.53) | KMT2AALDH1A1ALOX15SCN9A | |
| SCHEMBL2170332 | 0.88 | ALDH1A1 (0.53) | LMNAMEN1KMT2AALDH1A1SCN9A | |
| SCHEMBL2354704 | 0.88 | ALDH1A1 (0.50) | ALDH1A1CA1CA2CA7CA9 | |
| SCHEMBL2169958 | 0.87 | SCN9A (0.47) | LMNAMEN1KMT2AALDH1A1CA1 | |
| SCHEMBL2171621 | 0.87 | QRFPR (0.50) | ALDH1A1SCN9A | |
| SCHEMBL2169808 | 0.87 | SCN9A (0.48) | ALDH1A1SCN9A | |
| SCHEMBL2170146 | 0.85 | SCN9A (0.48) | LMNAMEN1KMT2AALDH1A1SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346821-A1 | SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS | Exelixis, Inc. (US) | 2011-07-27 | — | — | EP | disclosed |