SCHEMBL2170332

SCHEMBL2170332

NC(=O)C(Cc1ccc(Oc2ccc(F)cc2)cc1)NC(=O)CN1CCN(c2ccccc2F)CC1

nearest known ligand 0.53

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.53
TSHR P16473 6/20 0.53
SMN1; SMN2 Q16637 2/20 0.52
MAPK1 P28482 1/20 0.52
L3MBTL1 Q9Y468 1/20 0.49
HSD17B10 Q99714 1/20 0.49
KMT2A Q03164 3/20 0.48
NPSR1 Q6W5P4 3/20 0.48
MEN1 O00255 1/20 0.48
CYP1A2 P05177 1/20 0.48
CYP2C9 P11712 1/20 0.48
CYP2C19 P33261 1/20 0.48
SCN9A Q15858 2/20 0.47
PARP14 Q460N5 1/20 0.46
PARP10 Q53GL7 1/20 0.46
SCN10A Q9Y5Y9 1/20 0.46
LMNA P02545 2/20 0.45
MAPT P10636 1/20 0.45
HTT P42858 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2169959 0.90 TSHR (0.58) ALDH1A1TSHRSMN1; SMN2MAPK1KMT2A
SCHEMBL2170811 0.89 MAPT (0.54) ALDH1A1KMT2AMEN1SCN9ALMNA
SCHEMBL2170108 0.88 LMNA (0.52) ALDH1A1SMN1; SMN2KMT2AMEN1SCN9A
SCHEMBL2171096 0.85 SCN9A (0.51) ALDH1A1TSHRKMT2AMEN1SCN9A
SCHEMBL2354704 0.85 ALDH1A1 (0.50) ALDH1A1TSHRSMN1; SMN2SCN9AMAPT
SCHEMBL2170255 0.85 ALDH1A1 (0.57) ALDH1A1TSHRSMN1; SMN2L3MBTL1HSD17B10
SCHEMBL2171705 0.83 MEN1 (0.60) ALDH1A1TSHRSMN1; SMN2L3MBTL1KMT2A
SCHEMBL2169958 0.83 SCN9A (0.47) ALDH1A1KMT2AMEN1SCN9ALMNA
SCHEMBL2169808 0.82 SCN9A (0.48) ALDH1A1SCN9A
SCHEMBL2171851 0.82 KMT2A (0.53) ALDH1A1KMT2ASCN9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2349252-A2 SYNERGISTIC COMBINATION OF SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS AND ANTIMICROTUBULE AGENTS Exelixis, Inc. (US) 2011-08-03 EP disclosed
EP-2346821-A1 SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS Exelixis, Inc. (US) 2011-07-27 EP disclosed