Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.48 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2170108 | 0.95 | LMNA (0.52) | MAPTLMNAREV1ALDH1A1POLB | |
| SCHEMBL2171705 | 0.91 | MEN1 (0.60) | MAPTLMNAREV1ALDH1A1MEN1 | |
| SCHEMBL2170332 | 0.89 | ALDH1A1 (0.53) | MAPTLMNAALDH1A1SCN9AMEN1 | |
| SCHEMBL2171096 | 0.87 | SCN9A (0.51) | ALDH1A1POLBKDM4ESCN9AMEN1 | |
| SCHEMBL2354704 | 0.87 | ALDH1A1 (0.50) | MAPTALDH1A1KDM4ESCN9AHTT | |
| SCHEMBL2170255 | 0.86 | ALDH1A1 (0.57) | MAPTLMNAALDH1A1POLBKDM4E | |
| SCHEMBL2169959 | 0.86 | TSHR (0.58) | MAPTLMNAALDH1A1KDM4EUSP2 | |
| SCHEMBL2171851 | 0.86 | KMT2A (0.53) | ALDH1A1SCN9AKMT2A | |
| SCHEMBL2169958 | 0.84 | SCN9A (0.47) | LMNAALDH1A1SCN9AMEN1KMT2A | |
| SCHEMBL2169808 | 0.84 | SCN9A (0.48) | ALDH1A1SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349252-A2 | SYNERGISTIC COMBINATION OF SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS AND ANTIMICROTUBULE AGENTS | Exelixis, Inc. (US) | 2011-08-03 | — | — | EP | disclosed |
| EP-2346821-A1 | SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS | Exelixis, Inc. (US) | 2011-07-27 | — | — | EP | disclosed |