Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.49 |
| ▸ | THPO | P40225 | 2/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1269424 | 0.85 | CYP3A4 (0.54) | EGFRERBB2ALDH1A1CYP3A4SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL3838748 | 0.83 | CYP3A4 (0.52) | EGFRERBB2ALDH1A1CYP3A4SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4908898 | 0.83 | CYP3A4 (0.52) | EGFRERBB2ALDH1A1CYP3A4SMN1; SMN2 | |
| SCHEMBL12266656 | 0.83 | EGFR (0.58) | EGFRERBB2ALDH1A1CYP3A4SMN1; SMN2 | |
| SCHEMBL28280620 | 0.80 | EGFR (0.58) | EGFRERBB2ALDH1A1CYP3A4SMN1; SMN2 | |
| SCHEMBL11484155 | 0.79 | HPGD (0.56) | EGFRERBB2ALDH1A1MAPTLMNA | |
| SCHEMBL766052 | 0.78 | EGFR (0.61) | EGFRERBB2ALDH1A1CYP3A4SMN1; SMN2 | |
| SCHEMBL7462603 | 0.78 | EGFR (0.60) | EGFRERBB2ALDH1A1CYP3A4SMN1; SMN2 | |
| SCHEMBL14615156 | 0.78 | EGFR (0.64) | EGFRERBB2ALDH1A1CYP3A4SMN1; SMN2 | |
| SCHEMBL11980711 | 0.77 | EGFR (0.63) | EGFRERBB2ALDH1A1CYP3A4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8354547-B2 | 4β-amino podophyllotoxin congeners as anti tumour antibiotics a process for the preparation thereof | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2013-01-15 | — | — | US | claimed |
| US-20110213165-A1 | NOVEL 4BETA-AMINO PODOPHYLLOTOXIN CONGENERS AS ANTI TUMOUR ANTIBIOTICS A PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2011-09-01 | — | — | US | claimed |
| EP-2346876-A1 | NOVEL 4BETA-AMINO PODOPHVLLOTOXIN CONGENERS AS ANTI TUMOUR ANTIBIOTICS A PROCESS FOR THE PREPARATION THEREOF | Council of Scientific & Industrial Research (IN) | 2011-07-27 | — | — | EP | claimed |
| WO-2010052733-A1 | NOVEL 4β-AMINO PODOPHVLLOTOXIN CONGENERS AS ANTI TUMOUR ANTIBIOTICS A PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2010-05-14 | — | — | WO | claimed |
| EP-2346876-B1 | NOVEL 4BETA-AMINO PODOPHVLLOTOXIN CONGENERS AS ANTI TUMOUR ANTIBIOTICS A PROCESS FOR THE PREPARATION THEREOF | COUNCIL SCIENT IND RES (IN) | 2013-01-30 | — | — | EP | disclosed |
| US-8354547-B2 | 4β-amino podophyllotoxin congeners as anti tumour antibiotics a process for the preparation thereof | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2013-01-15 | — | — | US | disclosed |
| US-20110213165-A1 | NOVEL 4BETA-AMINO PODOPHYLLOTOXIN CONGENERS AS ANTI TUMOUR ANTIBIOTICS A PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2011-09-01 | — | — | US | disclosed |
| EP-2346876-A1 | NOVEL 4BETA-AMINO PODOPHVLLOTOXIN CONGENERS AS ANTI TUMOUR ANTIBIOTICS A PROCESS FOR THE PREPARATION THEREOF | Council of Scientific & Industrial Research (IN) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010052733-A1 | NOVEL 4β-AMINO PODOPHVLLOTOXIN CONGENERS AS ANTI TUMOUR ANTIBIOTICS A PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2010-05-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110213165-A1 | NOVEL 4BETA-AMINO PODOPHYLLOTOXIN CONGENERS AS ANTI TUMOUR ANTIBIOTICS A PROCESS FOR THE PREPARATION THEREOF | EIF4B, TUBB4B, TUBB4A | EGFR 489/4885ERBB2 373/4885ALDH1A1 1724/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.