SCHEMBL1269424

SCHEMBL1269424

Nc1ccc(N(CCCl)CCCl)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 6/20 0.54
ALDH1A1 P00352 6/20 0.54
TDP1 Q9NUW8 4/20 0.54
TSHR P16473 2/20 0.54
MAPK1 P28482 2/20 0.54
L3MBTL1 Q9Y468 2/20 0.54
PSMD14 O00487 1/20 0.54
RECQL P46063 1/20 0.54
GFER P55789 1/20 0.54
MAPT P10636 4/20 0.47
SMN1; SMN2 Q16637 3/20 0.47
HIF1A Q16665 3/20 0.47
ALOX15 P16050 3/20 0.47
LMNA P02545 3/20 0.47
NFKB1 P19838 2/20 0.47
THPO P40225 2/20 0.47
PMP22 Q01453 2/20 0.47
CYP1A2 P05177 2/20 0.47
KDM4E B2RXH2 2/20 0.47
MEN1 O00255 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL4908898 0.98 CYP3A4 (0.52) CYP3A4ALDH1A1TDP1TSHRMAPK1
Hydrochloric Acid SCHEMBL3838748 0.98 CYP3A4 (0.52) CYP3A4ALDH1A1TDP1TSHRMAPK1
SCHEMBL8813083 0.88 CYP3A4 (0.52) CYP3A4ALDH1A1TDP1TSHRMAPK1
SCHEMBL10975050 0.87 ALDH1A1 (0.69) CYP3A4ALDH1A1TDP1TSHRMAPK1
SCHEMBL15329275 0.87 CYP3A4 (0.47) CYP3A4ALDH1A1TDP1TSHRMAPK1
Hydrochloric Acid SCHEMBL7470284 0.86 ALDH1A1 (0.67) CYP3A4ALDH1A1TDP1TSHRMAPK1
SCHEMBL8810302 0.85 CYP3A4 (0.41) CYP3A4ALDH1A1TDP1TSHRMAPK1
SCHEMBL2170152 0.85 EGFR (0.54) CYP3A4ALDH1A1TDP1TSHRMAPK1
SCHEMBL7471448 0.79 ALDH1A1 (0.56) CYP3A4ALDH1A1TDP1TSHRL3MBTL1
SCHEMBL8599765 0.78 KMT2A (0.48) CYP3A4ALDH1A1TDP1TSHRMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 183 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118290306-B Nitrogen mustard derivative and preparation method thereof 西南科技大学 2025-03-04 CN claimed
CN-118290306-A Novel nitrogen mustard derivative and preparation method thereof 西南科技大学 2024-07-05 CN claimed
CN-109574960-B Docetaxel derivative and preparation method and application thereof 南京友怡医药科技有限公司 2023-03-21 CN claimed
CN-108948267-B P (HPMA) -nitrogen mustard high molecular polymer with anti-tumor activity and preparation method and application thereof 甘肃农业大学 2020-09-22 CN claimed
CN-106631857-B Arylamine nitrogen mustard derivatives N, N- bis- (2- chloroethyl)-N '-propiono -1,4- phenylenediamine and preparation method thereof 长安大学 2019-05-10 CN claimed
CN-106631874-B Arylamine nitrogen mustard derivatives N, N- bis- (2- chloroethyl)-N '-acetyl group -1,4- phenylenediamine and preparation method thereof 长安大学 2019-05-10 CN claimed
CN-106631857-A Aryl nitrogen mustard derivative N,N-di(2-chloroethyl)-N'-propionyl-1,4-phenylenediamine and preparation method thereof 长安大学 2017-05-10 CN claimed
CN-106631874-A Arylamine nitrogen mustard derivative N,N-bis(2-chloroethyl)-N'-acetyl-1,4-phenylenediamine and preparation method thereof 长安大学 2017-05-10 CN claimed
US-7705045-B2 compounds comprising a specifier linked to two or more of the same or different leaving groups via a self-eliminating multiple release spacer or spacer system, which compounds upon a single activation step, in particular removal or transformation of the specifier, release two or more leaving groups SYNTARGA, B.V. (NL) 2010-04-27 US claimed
US-20090076176-A1 Prodrugs activated by plasmin and their use in cancer chemotherapy MEDAREX, INC. (US) 2009-03-19 US claimed
US-20060116422-A1 Prodrugs built as multiple self-elimination-release spacers SYNTARGA B.V. (NL) 2006-06-01 US claimed
EP-1560599-A1 PRODRUGS BUILT AS MULTIPLE SELF-ELIMINATION-RELEASE SPACERS Syntarga B.V. (NL) 2005-08-10 EP claimed
US-20040171562-A1 Prodrugs activated by plasmin and their use in cancer chemotherapy E. R. SQUIBB & SONS, L.L.C. 2004-09-02 US claimed
WO-2004043493-A1 PRODRUGS BUILT AS MULTIPLE SELF-ELIMINATION-RELEASE SPACERS SYNTARGA B.V. (NL) 2004-05-27 WO claimed
EP-0891191-A1 ANTI-TUMOUR AGENT THE UNIVERSITY OF BIRMINGHAM (GB) 1999-01-20 EP claimed
WO-1997036616-A2 ANTI-TUMOUR AGENT THE UNIVERSITY OF BIRMINGHAM (GB) 1997-10-09 WO claimed
EP-0742015-A1 Prodrugs for beta-lactamase and uses thereof Bristol-Myers Squibb Company (US) 1996-11-13 EP claimed
EP-0484870-A2 Prodrugs for beta-lactamase and uses thereof Bristol-Myers Squibb Company (US) 1992-05-13 EP claimed
US-4017471-A ANTITUMOR AGENT G. D. SEARLE & CO. (EN) 1977-04-12 US claimed
EP-4688849-A1 BLOOD-BRAIN BARRIER CROSSING ANTIBODIES VIB VZW (BE) 2026-02-11 EP disclosed
US-20250304677-A1 Blood-Cerebrospinal Fluid Barrier Crossing Antibodies KATHOLIEKE UNIVERSITEIT LEUVEN (BE) 2025-10-02 US disclosed
US-20250297004-A1 NECTIN-4 BINDING AGENTS INNATE PHARMA (FR) 2025-09-25 US disclosed
EP-4532020-A1 NECTIN-4 BINDING AGENTS Innate Pharma (FR) 2025-04-09 EP disclosed
CN-118290306-B Nitrogen mustard derivative and preparation method thereof 西南科技大学 2025-03-04 CN disclosed
CN-118290306-B Nitrogen mustard derivative and preparation method thereof 西南科技大学 2025-03-04 CN disclosed
WO-2024208816-A1 BLOOD-BRAIN BARRIER CROSSING ANTIBODIES VIB VZW (BE) 2024-10-10 WO disclosed
US-20240325557-A1 TREATMENT OF CANCER INNATE PHARMA (FR) 2024-10-03 US disclosed
EP-4406585-A2 NUCLEIC ACID PRODUCTS AND METHODS OF ADMINISTRATION THEREOF Factor Bioscience Inc. (US) 2024-07-31 EP disclosed
CN-118290306-A Novel nitrogen mustard derivative and preparation method thereof 西南科技大学 2024-07-05 CN disclosed
CN-118290306-A Novel nitrogen mustard derivative and preparation method thereof 西南科技大学 2024-07-05 CN disclosed
US-20240156987-A1 NUCLEIC ACID PRODUCTS AND METHODS OF ADMINISTRATION THEREOF FACTOR BIOSCIENCE INC. 2024-05-16 US disclosed
US-11904023-B2 Nucleic acid products and methods of administration thereof FACTOR BIOSCIENCE INC. (US) 2024-02-20 US disclosed
WO-2024008755-A1 BLOOD-CEREBROSPINAL FLUID BARRIER CROSSING ANTIBODIES VIB VZW (BE) 2024-01-11 WO disclosed
US-11834513-B2 Antibodies to MUC16 and methods of use thereof MEMORIAL SLOAN KETTERING CANCER CENTER (US) 2023-12-05 US disclosed
WO-2023227660-A1 NECTIN-4 BINDING AGENTS INNATE PHARMA (FR) 2023-11-30 WO disclosed
US-11826399-B2 Chlorotoxin agents and uses thereof EISAI INC. (US) 2023-11-28 US disclosed
CN-116964196-A Recombinant oncolytic virus and medical application thereof 深圳艾欣达伟医药科技有限公司 2023-10-27 CN disclosed
EP-4251207-A1 TREATMENT OF CANCER Innate Pharma (FR) 2023-10-04 EP disclosed
CN-109574960-B Docetaxel derivative and preparation method and application thereof 南京友怡医药科技有限公司 2023-03-21 CN disclosed
US-20230040245-A1 FREE PSA ANTIBODIES AS DIAGNOSTICS, PROGNOSTICS AND THERAPEUTICS FOR PROSTATE CANCER MEMORIAL SLOAN-KETTERING CANCER CENTER 2023-02-09 US disclosed
US-20230015146-A1 NUCLEIC ACID PRODUCTS AND METHODS OF ADMINISTRATION THEREOF FACTOR BIOSCIENCE INC. 2023-01-19 US disclosed
US-11518996-B2 Methods and compositions for treating cancer using peptide nucleic acid-based agents MEMORIAL SLOAN-KETTERING CANCER CENTER (US) 2022-12-06 US disclosed
WO-2022206962-A1 RECOMBINANT ONCOLYTIC VIRUS AND MEDICAL USE THEREOF 深圳艾欣达伟医药科技有限公司 2022-10-06 WO disclosed
US-11446400-B2 Free PSA antibodies as diagnostics, prognostics and therapeutics for prostate cancer MEMORIAL SLOAN KETTERING CANCER CENTER (US) 2022-09-20 US disclosed
EP-2911666-B1 MODULATORS OF RESISTANT ANDROGEN RECEPTOR MEMORIAL SLOAN KETTERING CANCER CENTER (US) 2022-08-24 EP disclosed
WO-2022112356-A1 TREATMENT OF CANCER INNATE PHARMA (FR) 2022-06-02 WO disclosed
EP-4003389-A1 METHODS AND COMPOSITIONS FOR TREATING CANCER USING PEPTIDE NUCLEIC ACID-BASED AGENTS The Trustees Of Columbia University In The City Of New York (US) 2022-06-01 EP disclosed
CN-114502202-A Methods and compositions for treating cancer by using peptide nucleic acid-based agents 纽约市哥伦比亚大学理事会 2022-05-13 CN disclosed
US-20220144898-A1 METHODS AND COMPOSITIONS FOR TREATING CANCER USING PEPTIDE NUCLEIC ACID-BASED AGENTS THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK 2022-05-12 US disclosed
EP-3010547-B1 ENZYMATIC CONJUGATION OF POLYPEPTIDES INNATE PHARMA (FR) 2021-04-21 EP disclosed
EP-2793947-B1 ENZYMATIC CONJUGATION OF POLYPEPTIDES INNATE PHARMA (FR) 2021-02-03 EP disclosed
US-20200384002-A1 Prodrugs Activated by Reduction in the Cytosol UNIV YALE (US) 2020-12-10 US disclosed
CN-108948267-B P (HPMA) -nitrogen mustard high molecular polymer with anti-tumor activity and preparation method and application thereof 甘肃农业大学 2020-09-22 CN disclosed
EP-2968582-B1 SOLID PHASE TGASE-MEDIATED CONJUGATION OF ANTIBODIES INNATE PHARMA (FR) 2020-07-01 EP disclosed
US-10675359-B2 Enzymatic conjugation of antibodies INNATE PHARMA (FR) 2020-06-09 US disclosed
US-10611824-B2 Solid phase TGase-mediated conjugation of antibodies INNATE PHARMA (FR) 2020-04-07 US disclosed
EP-3564259-A2 RECOGNITION TAGS FOR TGASE-MEDIATED CONJUGATION Innate Pharma (FR) 2019-11-06 EP disclosed
US-10434180-B2 Enzymatic conjugation of polypeptides INNATE PHARMA (FR) 2019-10-08 US disclosed
WO-2019113227-A1 PRODRUGS ACTIVATED BY REDUCTION IN THE CYTOSOL YALE UNIVERSITY (US) 2019-06-13 WO disclosed
US-20190169601-A1 RECOGNITION TAGS FOR TGASE-MEDIATED CONJUGATION INNATE PHARMA (FR) 2019-06-06 US disclosed
CN-106631874-B Arylamine nitrogen mustard derivatives N, N- bis- (2- chloroethyl)-N '-acetyl group -1,4- phenylenediamine and preparation method thereof 长安大学 2019-05-10 CN disclosed
CN-106631874-B Arylamine nitrogen mustard derivatives N, N- bis- (2- chloroethyl)-N '-acetyl group -1,4- phenylenediamine and preparation method thereof 长安大学 2019-05-10 CN disclosed
CN-106631857-B Arylamine nitrogen mustard derivatives N, N- bis- (2- chloroethyl)-N '-propiono -1,4- phenylenediamine and preparation method thereof 长安大学 2019-05-10 CN disclosed
CN-106631857-B Arylamine nitrogen mustard derivatives N, N- bis- (2- chloroethyl)-N '-propiono -1,4- phenylenediamine and preparation method thereof 长安大学 2019-05-10 CN disclosed
CN-106631876-B (2- the chloroethyl)-N '-myristoyl of nitrogen mustard derivatives N, N- bis- base-Isosorbide-5-Nitrae-phenylenediamine and preparation method thereof 长安大学 2019-05-03 CN disclosed
CN-106631875-B Nitrogen mustard derivatives N, N- bis- (2- chloroethyl)-N '-hexadecanoyl group -1,4- phenylenediamine and preparation method thereof 长安大学 2019-05-03 CN disclosed
CN-106631875-B Nitrogen mustard derivatives N, N- bis- (2- chloroethyl)-N '-hexadecanoyl group -1,4- phenylenediamine and preparation method thereof 长安大学 2019-05-03 CN disclosed
CN-106631876-B (2- the chloroethyl)-N '-myristoyl of nitrogen mustard derivatives N, N- bis- base-Isosorbide-5-Nitrae-phenylenediamine and preparation method thereof 长安大学 2019-05-03 CN disclosed
EP-2872894-B1 SCREENING OF CONJUGATED ANTIBODIES INNATE PHARMA (FR) 2019-04-17 EP disclosed
US-10246510-B2 KIR3DL2 binding agents INNATE PHARMA (FR) 2019-04-02 US disclosed
CN-106631856-B Nitrogen mustard derivatives N, N- bis- (2- chloroethyl)-N '-benzoyl -1,4- phenylenediamine and preparation method thereof 长安大学 2019-03-19 CN disclosed
CN-106631856-B Nitrogen mustard derivatives N, N- bis- (2- chloroethyl)-N '-benzoyl -1,4- phenylenediamine and preparation method thereof 长安大学 2019-03-19 CN disclosed
EP-2897979-B1 KIR3DL2 BINDING AGENTS INNATE PHARMA (FR) 2019-02-13 EP disclosed
EP-1909846-B1 TRIAZOLE-CONTAINING RELEASABLE LINKERS, CONJUGATES COMPRISING THE SAME AND PROCESSES FOR THEIR PREPARATION SYNTARGA BV (NL) 2018-12-26 EP disclosed
US-10132799-B2 Screening of conjugated antibodies INNATE PHARMA (FR) 2018-11-20 US disclosed
US-10071169-B2 Enzymatic conjugation of polypeptides INNATE PHARMA (FR) 2018-09-11 US disclosed
EP-2793949-B1 ENZYMATIC CONJUGATION OF ANTIBODIES INNATE PHARMA (FR) 2018-08-22 EP disclosed
US-10036010-B2 Recognition tags for TGase-mediated conjugation INNATE PHARMA (FR) 2018-07-31 US disclosed
US-20180193476-A1 ENZYMATIC CONJUGATION OF ANTIBODIES ARARIS BIOTECH LTD (CH) 2018-07-12 US disclosed
US-20180071402-A1 ENZYMATIC CONJUGATION OF POLYPEPTIDES INNATE PHARMA (FR) 2018-03-15 US disclosed
US-9764038-B2 Enzymatic conjugation of antibodies INNATE PHARMA (FR) 2017-09-19 US disclosed
US-9717803-B2 Enzymatic conjugation of polypeptides INNATE PHARMA (FR) 2017-08-01 US disclosed
CN-106631874-A Arylamine nitrogen mustard derivative N,N-bis(2-chloroethyl)-N'-acetyl-1,4-phenylenediamine and preparation method thereof 长安大学 2017-05-10 CN disclosed
CN-106631857-A Aryl nitrogen mustard derivative N,N-di(2-chloroethyl)-N'-propionyl-1,4-phenylenediamine and preparation method thereof 长安大学 2017-05-10 CN disclosed
CN-106631856-A Nitrogen mustard derivative N,N-di(2-chloroethyl)-N'-benzoyl-1,4-phenylenediamine and preparation method thereof 长安大学 2017-05-10 CN disclosed
CN-106631857-A Aryl nitrogen mustard derivative N,N-di(2-chloroethyl)-N'-propionyl-1,4-phenylenediamine and preparation method thereof 长安大学 2017-05-10 CN disclosed
CN-106631856-A Nitrogen mustard derivative N,N-di(2-chloroethyl)-N'-benzoyl-1,4-phenylenediamine and preparation method thereof 长安大学 2017-05-10 CN disclosed
CN-106631875-A Nitrogen mustard derivative N,N-di(2-chloroethyl)-N'-hexadecanoyl-1,4-phenylenediamine and preparation method thereof 长安大学 2017-05-10 CN disclosed
CN-106631876-A Nitrogen mustard derivative N,N-di(2-chloroethyl)-N'-myristoyl-1,4-phenylenediamine and preparation method thereof 长安大学 2017-05-10 CN disclosed
CN-106631875-A Nitrogen mustard derivative N,N-di(2-chloroethyl)-N'-hexadecanoyl-1,4-phenylenediamine and preparation method thereof 长安大学 2017-05-10 CN disclosed
CN-106631876-A Nitrogen mustard derivative N,N-di(2-chloroethyl)-N'-myristoyl-1,4-phenylenediamine and preparation method thereof 长安大学 2017-05-10 CN disclosed
CN-106631874-A Arylamine nitrogen mustard derivative N,N-bis(2-chloroethyl)-N'-acetyl-1,4-phenylenediamine and preparation method thereof 长安大学 2017-05-10 CN disclosed
US-20160331842-A1 ENZYMATIC CONJUGATION OF POLYPEPTIDES ARARIS BIOTECH LTD (CH) 2016-11-17 US disclosed
US-9427478-B2 Enzymatic conjugation of polypeptides INNATE PHARMA (FR) 2016-08-30 US disclosed
US-20160114056-A1 ENZYMATIC CONJUGATION OF POLYPEPTIDES ARARIS BIOTECH LTD (CH) 2016-04-28 US disclosed
EP-3010547-A1 ENZYMATIC CONJUGATION OF POLYPEPTIDES Innate Pharma (FR) 2016-04-27 EP disclosed
EP-3010548-A1 ENZYMATIC CONJUGATION OF POLYPEPTIDES Innate Pharma (FR) 2016-04-27 EP disclosed
US-20160022833-A1 SOLID PHASE TGASE-MEDIATED CONJUGATION OF ANTIBODIES ARARIS BIOTECH LTD (CH) 2016-01-28 US disclosed
EP-2968582-A1 SOLID PHASE TGASE-MEDIATED CONJUGATION OF ANTIBODIES Innate Pharma (FR) 2016-01-20 EP disclosed
US-20150346195-A1 SCREENING OF CONJUGATED ANTIBODIES ARARIS BIOTECH LTD (CH) 2015-12-03 US disclosed
US-9193687-B2 Phenyl N-mustard linked to DNA-affinic molecules or water-soluble aryl rings, method and their use as cancer therapeutic agents ACADEMIA SINICA (TW) 2015-11-24 US disclosed
US-9193687-B2 Phenyl N-mustard linked to DNA-affinic molecules or water-soluble aryl rings, method and their use as cancer therapeutic agents ACADEMIA SINICA (TW) 2015-11-24 US disclosed
US-9193687-B2 Phenyl N-mustard linked to DNA-affinic molecules or water-soluble aryl rings, method and their use as cancer therapeutic agents ACADEMIA SINICA (TW) 2015-11-24 US disclosed
US-20150291692-A1 KIR3DL2 BINDING AGENTS INNATE PHARMA (FR) 2015-10-15 US disclosed
US-20150284713-A1 RECOGNITION TAGS FOR TGASE-MEDIATED CONJUGATION ARARIS BIOTECH LTD (CH) 2015-10-08 US disclosed
EP-2916872-A1 RECOGNITION TAGS FOR TGASE-MEDIATED CONJUGATION Innate Pharma (FR) 2015-09-16 EP disclosed
EP-2897979-A1 KIR3DL2 BINDING AGENTS Innate Pharma (FR) 2015-07-29 EP disclosed
US-20150165064-A1 ENZYMATIC CONJUGATION OF POLYPEPTIDES ARARIS BIOTECH LTD (CH) 2015-06-18 US disclosed
EP-2872894-A2 SCREENING OF CONJUGATED ANTIBODIES Innate Pharma (FR) 2015-05-20 EP disclosed
WO-2014202773-A1 ENZYMATIC CONJUGATION OF POLYPEPTIDES INNATE PHARMA (FR) 2014-12-24 WO disclosed
WO-2014202775-A1 ENZYMATIC CONJUGATION OF POLYPEPTIDES INNATE PHARMA (FR) 2014-12-24 WO disclosed
US-20140356385-A1 ENZYMATIC CONJUGATION OF ANTIBODIES ARARIS BIOTECH LTD (CH) 2014-12-04 US disclosed
EP-2793949-A1 ENZYMATIC CONJUGATION OF ANTIBODIES Innate Pharma (FR) 2014-10-29 EP disclosed
EP-2793947-A2 ENZYMATIC CONJUGATION OF POLYPEPTIDES Innate Pharma (FR) 2014-10-29 EP disclosed
WO-2014140300-A1 SOLID PHASE TGASE-MEDIATED CONJUGATION OF ANTIBODIES INNATE PHARMA (FR) 2014-09-18 WO disclosed
WO-2014072482-A1 RECOGNITION TAGS FOR TGASE-MEDIATED CONJUGATION INNATE PHARMA (FR) 2014-05-15 WO disclosed
WO-2014044681-A1 KIR3DL2 BINDING AGENTS INNATE PHARMA (FR) 2014-03-27 WO disclosed
WO-2014009426-A2 SCREENING OF CONJUGATED ANTIBODIES INNATE PHARMA (FR) 2014-01-16 WO disclosed
US-20130189287-A1 ENZYMATIC CONJUGATION OF POLYPEPTIDES PAUL SCHERRER INSTITUT 2013-07-25 US disclosed
US-20130178494-A1 PHENYL N-MUSTARD LINKED TO DNA-AFFINIC MOLECULES OR WATER-SOLUBLE ARYL RINGS, METHOD AND THEIR USE AS CANCER THERAPEUTIC AGENTS ACADEMIA SINICA (TW) 2013-07-11 US disclosed
US-20130178494-A1 PHENYL N-MUSTARD LINKED TO DNA-AFFINIC MOLECULES OR WATER-SOLUBLE ARYL RINGS, METHOD AND THEIR USE AS CANCER THERAPEUTIC AGENTS ACADEMIA SINICA (TW) 2013-07-11 US disclosed
US-20130178494-A1 PHENYL N-MUSTARD LINKED TO DNA-AFFINIC MOLECULES OR WATER-SOLUBLE ARYL RINGS, METHOD AND THEIR USE AS CANCER THERAPEUTIC AGENTS ACADEMIA SINICA (TW) 2013-07-11 US disclosed
WO-2013092998-A1 ENZYMATIC CONJUGATION OF ANTIBODIES INNATE PHARMA (FR) 2013-06-27 WO disclosed
WO-2013092983-A2 ENZYMATIC CONJUGATION OF POLYPEPTIDES INNATE PHARMA (FR) 2013-06-27 WO disclosed
US-8309554-B2 Hypoxia activated drugs of nitrogen mustard alkylators THRESHOLD PHARMACEUTICALS (US) 2012-11-13 US disclosed
US-8309554-B2 Hypoxia activated drugs of nitrogen mustard alkylators THRESHOLD PHARMACEUTICALS (US) 2012-11-13 US disclosed
US-8236985-B2 Compounds and uses thereof IMPERIAL INNOVATIONS LTD. (GB) 2012-08-07 US disclosed
US-8222297-B2 e.g. 1-[3-(acridin-9-ylamino)-5-hydroxymethylphenyl]-3-{4-[bis(2-chloroethyl)amino]phenyl}urea; anticarcinogenic agent; improved chemical stability and efficacy; brain tumor, breast cancer, colon cancer, leukemia, and neuroblastoma ACADEMIA SINICA (TW) 2012-07-17 US disclosed
US-8222297-B2 e.g. 1-[3-(acridin-9-ylamino)-5-hydroxymethylphenyl]-3-{4-[bis(2-chloroethyl)amino]phenyl}urea; anticarcinogenic agent; improved chemical stability and efficacy; brain tumor, breast cancer, colon cancer, leukemia, and neuroblastoma ACADEMIA SINICA (TW) 2012-07-17 US disclosed
US-8158590-B2 Triazole-containing releasable linkers, conjugates thereof, and methods of preparation SYNTARGA B.V. (NL) 2012-04-17 US disclosed
US-20110190310-A1 Hypoxia Activated Drugs Of Nitrogen Mustard Alkylators THRESHOLD PHARMACEUTICALS, INC. 2011-08-04 US disclosed
US-20110190310-A1 Hypoxia Activated Drugs Of Nitrogen Mustard Alkylators THRESHOLD PHARMACEUTICALS, INC. 2011-08-04 US disclosed
US-7893023-B2 Prodrugs activated by plasmin and their use in cancer chemotherapy MEDAREX, INC. (US) 2011-02-22 US disclosed
US-7705045-B2 compounds comprising a specifier linked to two or more of the same or different leaving groups via a self-eliminating multiple release spacer or spacer system, which compounds upon a single activation step, in particular removal or transformation of the specifier, release two or more leaving groups SYNTARGA, B.V. (NL) 2010-04-27 US disclosed
US-20100063144-A1 COMPOUNDS AND USES THEREOF IMPERIAL INNOVATIONS LTD (GB) 2010-03-11 US disclosed
WO-2009140553-A2 HYPOXIA ACTIVATED DRUGS OF NITROGEN MUSTARD ALKYLATORS THRESHOLD PHARMACEUTICALS, INC. (US) 2009-11-19 WO disclosed
EP-1037649-B1 POLYMERIC PRODRUGS OF AMINO- AND HYDROXYL-CONTAINING BIOACTIVE AGENTS ENZON INC (US) 2009-09-30 EP disclosed
US-7544477-B2 Identifying oligopeptides using interaction-dependent enzyme activation system; high-throughput assay KALOBIOS, INC. (US) 2009-06-09 US disclosed
US-20090076176-A1 Prodrugs activated by plasmin and their use in cancer chemotherapy MEDAREX, INC. (US) 2009-03-19 US disclosed
US-20080311136-A1 Triazole-Containing Releasable Linkers, Conjugates Thereof, and Methods of Preparation BYONDIS B.V. (NL) 2008-12-18 US disclosed
US-20080226601-A1 Herpes Virus-Based Compositions and Methods of Use in the Prenatal and Perinatal Periods UNIVERSITY OF ROCHESTER (US) 2008-09-18 US disclosed
US-7402556-B2 Prodrugs activated by plasmin and their use in cancer chemotherapy MEDAREX, INC. (US) 2008-07-22 US disclosed
US-20080171765-A1 Aniline or phenol mustards linked to DNA-affinic molecules or water-soluble aromatic rings and their use as cancer therapeutic agents ACADEMIA SINICA (TW) 2008-07-17 US disclosed
US-20080171765-A1 Aniline or phenol mustards linked to DNA-affinic molecules or water-soluble aromatic rings and their use as cancer therapeutic agents ACADEMIA SINICA (TW) 2008-07-17 US disclosed
US-7335478-B2 Reactivation-based molecular interaction sensors KALOBIOS PHARMACEUTICALS, INC. (US) 2008-02-26 US disclosed
US-20060116422-A1 Prodrugs built as multiple self-elimination-release spacers SYNTARGA B.V. (NL) 2006-06-01 US disclosed
EP-1041995-B1 TRIALKYL-LOCK-FACILITATED POLYMERIC PRODRUGS OF AMINO-CONTAINING BIOACTIVE AGENTS ENZON INC (US) 2006-03-08 EP disclosed
US-20050209320-A1 Anti-cancer compounds and methods of use thereof GTX, INC. 2005-09-22 US disclosed
EP-1560599-A1 PRODRUGS BUILT AS MULTIPLE SELF-ELIMINATION-RELEASE SPACERS Syntarga B.V. (NL) 2005-08-10 EP disclosed
US-20040171562-A1 Prodrugs activated by plasmin and their use in cancer chemotherapy E. R. SQUIBB & SONS, L.L.C. 2004-09-02 US disclosed
WO-2004043493-A1 PRODRUGS BUILT AS MULTIPLE SELF-ELIMINATION-RELEASE SPACERS SYNTARGA B.V. (NL) 2004-05-27 WO disclosed
EP-1064257-B1 ANTI-TUMOUR AGENTS ASTRAZENECA AB (SE) 2003-01-29 EP disclosed
EP-1064253-B1 ANTI-TUMOUR AGENTS ASTRAZENECA AB (SE) 2003-01-29 EP disclosed
US-6472435-B1 ANTITUMOR ANTIPROLIFERATION AGENT FORMED BY AMIDATION OF CARBOXY ACID WITH AROMATIC AMINE COMPOUND ASTRAZENECA AB (SE) 2002-10-29 US disclosed
EP-0711768-B1 BENZIMIDAZOLE DERIVATIVE MITSUI CHEMICALS INC (JP) 2002-02-13 EP disclosed
US-6346633-B1 TERT-AMINOPHENYLESTER OF ACID ASTRAZENECA AB (SE) 2002-02-12 US disclosed
US-6303569-B1 POLYMERIC-BASED DOUBLE PRODRUGS HAVING REVERSIBLE LINKAGES INVOLVING AMINO OR HYDROXYL MOIETIES OF CHEMICAL COMPOUNDS AND BIOLOGICALLY ACTIVE MATERIALS SUCH AS ENZYMES, PROTEINS ENZON, INC. 2001-10-16 US disclosed
US-6180095-B1 FOR DRUG DELIVERY ENZON, INC. 2001-01-30 US disclosed
EP-1064253-A1 ANTI-TUMOUR AGENTS AstraZeneca AB (SE) 2001-01-03 EP disclosed
EP-1064257-A1 ANTI-TUMOUR AGENTS AstraZeneca AB (SE) 2001-01-03 EP disclosed
US-6011042-A POLYMERIC PRODRUGS ARE PREFERABLY ESTERS OF HYDROXYL-CONTAINING AROMATIC COMPOUNDS AND ARE FORMED BY REACTING A DESIRED AROMATIC, HYDROXYL-CONTAINING COMPOUND WITH A SUBSTANTIALLY NON-ANTIGENIC POLYMER ENZON, INC. (US) 2000-01-04 US disclosed
US-5965119-A Trialkyl-lock-facilitated polymeric prodrugs of amino-containing bioactive agents ENZON, INC. (US) 1999-10-12 US disclosed
WO-1999048857-A1 ANTI-TUMOUR AGENTS ASTRAZENECA AB (SE) 1999-09-30 WO disclosed
WO-1999048860-A1 ANTI-TUMOUR AGENTS ASTRAZENECA AB (SE) 1999-09-30 WO disclosed
US-5872129-A REACTING AROMATIC ALPHA-METHYL HALIDES WITH N-ALKYL OR N-ARYLDIETHANOLAMINES TO GIVE QUATERNARY DIOLS AND CONVERTING DIOLS TO HALOGEN OR SULFONATE DERIVATIVES BY TREATING WITH SULFONYL CHLORIDE; ANTITUMOR BLOOD FLOW AGENT AUCKLAND UNISERVICES LIMITED (NZ) 1999-02-16 US disclosed
EP-0891191-A1 ANTI-TUMOUR AGENT THE UNIVERSITY OF BIRMINGHAM (GB) 1999-01-20 EP disclosed
US-5852011-A Benzimidazole derivatives MITSUI CHEMICALS, INC. (JP) 1998-12-22 US disclosed
US-5821258-A ANTICARCINOGENIC AGENTS; ANTIVIRAL AGENTS; ANTIMICROBIAL AGENTS MITSUI CHEMICALS, INC. (JP) 1998-10-13 US disclosed
US-5773435-A ANTITUMOR AGENTS USING CEPHALOSPORINS BRISTOL-MYERS SQUIBB COMPANY (US) 1998-06-30 US disclosed
US-5691371-A ANTITUMOR AND -CARCINOGENIC AGENTS; PRODRUGS BIOREDUCED TO RELEASE A CYTOTOXIN, A MECHLORETHAMINE DERIVATIVE; WATER SOLUBLE AUCKLAND UNISERVICES LIMITED (NZ) 1997-11-25 US disclosed
WO-1997036616-A2 ANTI-TUMOUR AGENT THE UNIVERSITY OF BIRMINGHAM (GB) 1997-10-09 WO disclosed
EP-0745390-A2 Polymeric prodrugs for beta-lactamase and uses thereof BRISTOL-MYERS SQUIBB COMPANY (US) 1996-12-04 EP disclosed
EP-0742015-A1 Prodrugs for beta-lactamase and uses thereof Bristol-Myers Squibb Company (US) 1996-11-13 EP disclosed
EP-0719765-A2 Phenylbenzimidazole derivatives MITSUI TOATSU CHEMICALS, INC. (JP) 1996-07-03 EP disclosed
EP-0700376-A4 NITROBENZYL MUSTARD QUATERNARY SALTS AND THEIR USE AS HYPOXIA-SELECTIVE CYTOTOXIC AGENTS AUCKLAND UNISERVICES LTD (NZ) 1996-05-22 EP disclosed
EP-0711768-A1 BENZIMIDAZOLE DERIVATIVE MITSUI TOATSU CHEMICALS, Inc. (JP) 1996-05-15 EP disclosed
EP-0700376-A1 NITROBENZYL MUSTARD QUATERNARY SALTS AND THEIR USE AS HYPOXIA-SELECTIVE CYTOTOXIC AGENTS AUCKLAND UNISERVICES LIMITED (NZ) 1996-03-13 EP disclosed
WO-1994027954-A1 NITROBENZYL MUSTARD QUATERNARY SALTS AND THEIR USE AS HYPOXIA-SELECTIVE CYTOTOXIC AGENTS AUCKLAND UNISERVICES LIMITED (NZ) 1994-12-08 WO disclosed
EP-0484870-A2 Prodrugs for beta-lactamase and uses thereof Bristol-Myers Squibb Company (US) 1992-05-13 EP disclosed
EP-0192242-B1 SUBSTITUTED AMINOPHENYLUREA DERIVATIVES TOKUYAMA SODA KABUSHIKI KAISHA (JP) 1990-11-07 EP disclosed
US-4803223-A ANTITUMOR AGENTS TOKUYAMA SODA KABUSHIKI KAISHA (JP) 1989-02-07 US disclosed
US-4017471-A ANTITUMOR AGENT G. D. SEARLE & CO. (EN) 1977-04-12 US disclosed
US-4017471-A ANTITUMOR AGENT G. D. SEARLE & CO. (EN) 1977-04-12 US disclosed
US-4017471-A ANTITUMOR AGENT G. D. SEARLE & CO. (EN) 1977-04-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (35 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110190310-A1 Hypoxia Activated Drugs Of Nitrogen Mustard Alkylators HIF1AN, HIF1A, HYOU1 CYP3A4 567/4885ALDH1A1 325/4885TDP1 1240/4885
US-20200384002-A1 Prodrugs Activated by Reduction in the Cytosol TK1, MTHFD1, GOT1 CYP3A4 302/4885ALDH1A1 1315/4885TDP1 571/4885
US-10675359-B2 Enzymatic conjugation of antibodies DNPEP, MPO, FCGR3B CYP3A4 306/4885ALDH1A1 161/4885TDP1 1163/4885
US-20180193476-A1 ENZYMATIC CONJUGATION OF ANTIBODIES DNPEP, MPO, FCGR3B CYP3A4 306/4885ALDH1A1 161/4885TDP1 1163/4885
US-20130189287-A1 ENZYMATIC CONJUGATION OF POLYPEPTIDES DNPEP, ENPEP, PEPD CYP3A4 737/4885ALDH1A1 484/4885TDP1 949/4885
US-10246510-B2 KIR3DL2 binding agents KLRK1, KCNA3, KCNK3 CYP3A4 2294/4885ALDH1A1 1403/4885TDP1 4398/4885
US-20180071402-A1 ENZYMATIC CONJUGATION OF POLYPEPTIDES DNPEP, ENPEP, PEPD CYP3A4 636/4885ALDH1A1 468/4885TDP1 914/4885
US-10611824-B2 Solid phase TGase-mediated conjugation of antibodies TGM3, TGM2, TGM6 CYP3A4 204/4885ALDH1A1 1703/4885TDP1 879/4885
US-20080171765-A1 Aniline or phenol mustards linked to DNA-affinic molecules or water-soluble aromatic rings and their use as cancer therapeutic agents WEE1, PCNA, ATIC CYP3A4 1084/4885ALDH1A1 1144/4885TDP1 684/4885
US-20240156987-A1 NUCLEIC ACID PRODUCTS AND METHODS OF ADMINISTRATION THEREOF STING1, MITF, RARA CYP3A4 4878/4885ALDH1A1 1410/4885TDP1 448/4885
US-20060116422-A1 Prodrugs built as multiple self-elimination-release spacers DNPEP, GUSB, APEH CYP3A4 210/4885ALDH1A1 1189/4885TDP1 2056/4885
US-20230015146-A1 NUCLEIC ACID PRODUCTS AND METHODS OF ADMINISTRATION THEREOF STING1, MITF, RARA CYP3A4 4878/4885ALDH1A1 1410/4885TDP1 448/4885
US-10434180-B2 Enzymatic conjugation of polypeptides DNPEP, ENPEP, PEPD CYP3A4 561/4885ALDH1A1 415/4885TDP1 696/4885
US-11826399-B2 Chlorotoxin agents and uses thereof NRP1, LCP1, CLSPN CYP3A4 3246/4885ALDH1A1 612/4885TDP1 676/4885
US-20080311136-A1 Triazole-Containing Releasable Linkers, Conjugates Thereof, and Methods of Preparation PAICS, CD44, TRIM33 CYP3A4 680/4885ALDH1A1 613/4885TDP1 925/4885
US-10132799-B2 Screening of conjugated antibodies FCGR2A, TGM2, TGM6 CYP3A4 2934/4885ALDH1A1 2044/4885TDP1 3189/4885
US-20250297004-A1 NECTIN-4 BINDING AGENTS NECTIN4, VCAM1, EPCAM CYP3A4 2890/4885ALDH1A1 1865/4885TDP1 4431/4885
US-20090076176-A1 Prodrugs activated by plasmin and their use in cancer chemotherapy PLG, PLAT, DNPEP CYP3A4 908/4885ALDH1A1 2535/4885TDP1 1288/4885
US-10036010-B2 Recognition tags for TGase-mediated conjugation TGM2, TGM3, TGM6 CYP3A4 2693/4885ALDH1A1 3578/4885TDP1 1188/4885
US-20140356385-A1 ENZYMATIC CONJUGATION OF ANTIBODIES DNPEP, MPO, FCGR3B CYP3A4 306/4885ALDH1A1 161/4885TDP1 1163/4885
US-20150284713-A1 RECOGNITION TAGS FOR TGASE-MEDIATED CONJUGATION TGM2, TGM3, TGM6 CYP3A4 2693/4885ALDH1A1 3578/4885TDP1 1188/4885
US-20150346195-A1 SCREENING OF CONJUGATED ANTIBODIES FCGR2A, TGM2, TGM6 CYP3A4 2934/4885ALDH1A1 2044/4885TDP1 3189/4885
US-20040171562-A1 Prodrugs activated by plasmin and their use in cancer chemotherapy PLG, PLAT, DNPEP CYP3A4 908/4885ALDH1A1 2535/4885TDP1 1288/4885
US-20160114056-A1 ENZYMATIC CONJUGATION OF POLYPEPTIDES DNPEP, ENPEP, PEPD CYP3A4 665/4885ALDH1A1 161/4885TDP1 559/4885
US-10071169-B2 Enzymatic conjugation of polypeptides DNPEP, ENPEP, PEPD CYP3A4 665/4885ALDH1A1 161/4885TDP1 559/4885
US-20160022833-A1 SOLID PHASE TGASE-MEDIATED CONJUGATION OF ANTIBODIES TGM2, TGM3, TGM6 CYP3A4 202/4885ALDH1A1 1768/4885TDP1 800/4885
US-20190169601-A1 RECOGNITION TAGS FOR TGASE-MEDIATED CONJUGATION TGM2, TGM3, TGM6 CYP3A4 2693/4885ALDH1A1 3578/4885TDP1 1188/4885
US-20150291692-A1 KIR3DL2 BINDING AGENTS MICA, NECTIN4, PDCD6 CYP3A4 1267/4885ALDH1A1 2721/4885TDP1 4351/4885
US-20130178494-A1 PHENYL N-MUSTARD LINKED TO DNA-AFFINIC MOLECULES OR WATER-SOLUBLE ARYL RINGS, METHOD AND THEIR USE AS CANCER THERAPEUTIC AGENTS PCNA, WEE1, UNG CYP3A4 3812/4885ALDH1A1 1712/4885TDP1 43/4885
US-20160331842-A1 ENZYMATIC CONJUGATION OF POLYPEPTIDES DNPEP, ENPEP, PEPD CYP3A4 561/4885ALDH1A1 415/4885TDP1 696/4885
US-11904023-B2 Nucleic acid products and methods of administration thereof STING1, MITF, RARA CYP3A4 4878/4885ALDH1A1 1410/4885TDP1 448/4885
US-20240325557-A1 TREATMENT OF CANCER NECTIN4, CD44, EPCAM CYP3A4 4347/4885ALDH1A1 1534/4885TDP1 3839/4885
US-20150165064-A1 ENZYMATIC CONJUGATION OF POLYPEPTIDES DNPEP, ENPEP, PEPD CYP3A4 561/4885ALDH1A1 415/4885TDP1 696/4885
US-20100063144-A1 COMPOUNDS AND USES THEREOF HDAC1, HDAC11, HDAC2 CYP3A4 251/4885ALDH1A1 150/4885TDP1 751/4885
US-20050209320-A1 Anti-cancer compounds and methods of use thereof AR, BRDT, BAD CYP3A4 3312/4885ALDH1A1 1269/4885TDP1 2576/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.