Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.47 |
| ▸ | HPGD | P15428 | 8/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.35 |
| ▸ | CBFB | Q13951 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CUL4A | Q13619 | 1/20 | 0.33 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20156962 | 0.71 | TRPV4 (0.44) | ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL20732021 | 0.71 | ALDH1A1 (0.47) | ALDH1A1KDM4EHPGDHSD11B1KMT2A | |
| SCHEMBL21180029 | 0.64 | KAT2B (0.49) | ALDH1A1KDM4ELMNAMAPTGAA | |
| SCHEMBL29054645 | 0.63 | HSD11B1 (0.41) | ALDH1A1KDM4EHPGDLMNAHSD11B1 | |
| SCHEMBL24056640 | 0.63 | CHEK1 (0.49) | — | |
| SCHEMBL20732206 | 0.62 | ALDH1A1 (0.52) | ALDH1A1KDM4EHPGDLMNAHSD11B1 | |
| SCHEMBL20156858 | 0.60 | TSHR (0.58) | ALDH1A1KDM4EHPGDLMNAKMT2A | |
| SCHEMBL30317451 | 0.60 | TSHR (0.58) | ALDH1A1KDM4EHPGDLMNAKMT2A | |
| SCHEMBL9748593 | 0.60 | MAPK1 (0.50) | ALDH1A1KDM4EHPGDLMNAPOLB | |
| SCHEMBL20732207 | 0.59 | KDM4E (0.34) | ALDH1A1KDM4EHPGDHSD11B1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020033707-A1 | CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2020-02-13 | — | — | WO | disclosed |