Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.67 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.60 |
| ▸ | LTA4H | P09960 | 1/20 | 0.57 |
| ▸ | MAOB | P27338 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.55 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.55 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.55 |
| ▸ | RXRA | P19793 | 1/20 | 0.55 |
| ▸ | RXRB | P28702 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8833698 | 0.88 | ALOX5 (0.62) | ALOX5LTA4HMAOBNR4A1NR4A2 | |
| SCHEMBL2885897 | 0.88 | ALOX5 (0.62) | ALOX5LTA4HMAOBNR4A1NR4A2 | |
| Hydrochloric Acid SCHEMBL6948842 | 0.86 | ALOX5 (0.60) | ALOX5LTA4HMAOBNR4A1NR4A2 | |
| SCHEMBL6948837 | 0.85 | ALOX5 (0.59) | ALOX5LTA4HMAOBNR4A1NR4A2 | |
| SCHEMBL9577464 | 0.85 | ALOX5 (0.59) | ALOX5LTA4HMAOBNR4A1NR4A2 | |
| SCHEMBL28353364 | 0.84 | MRGPRX4 (0.59) | ALOX5PARP10MAOBNPC1RAB9A | |
| SCHEMBL6266373 | 0.84 | LTA4H (0.59) | ALOX5LTA4HMAOBNPC1RAB9A | |
| SCHEMBL7401422 | 0.82 | LMNA (0.71) | ALOX5MAOBNR4A1NR4A2NR4A3 | |
| SCHEMBL28724154 | 0.82 | LMNA (0.70) | ALOX5PARP10LTA4HMAOBNPC1 | |
| SCHEMBL28115187 | 0.82 | PARP10 (0.60) | ALOX5PARP10MAOBRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349252-A2 | SYNERGISTIC COMBINATION OF SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS AND ANTIMICROTUBULE AGENTS | Exelixis, Inc. (US) | 2011-08-03 | — | — | EP | disclosed |
| EP-2346821-A1 | SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS | Exelixis, Inc. (US) | 2011-07-27 | — | — | EP | disclosed |
| EP-0337714-A2 | HIV protease inhibitors useful for the treatment of aids | MERCK & CO. INC. (US) | 1989-10-18 | — | — | EP | disclosed |