Sugi Predict

Sugi Predict / Compounds / SCHEMBL2885897

SCHEMBL2885897

SCHEMBL2885897

CC(C(=O)O)c1ccc(OCc2ccccc2)cc1

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALOX5 P09917 1/20 0.62
▸ MAOB P27338 1/20 0.59
▸ NR4A1 P22736 1/20 0.58
▸ NR4A2 P43354 1/20 0.58
▸ NR4A3 Q92570 1/20 0.58
▸ PPARG P37231 1/20 0.57
▸ PPARA Q07869 1/20 0.57
▸ RXRA P19793 1/20 0.57
▸ RXRB P28702 1/20 0.57
▸ LMNA P02545 2/20 0.57
▸ L3MBTL1 Q9Y468 1/20 0.57
▸ FFAR1 O14842 1/20 0.57
▸ ACACB O00763 1/20 0.56
▸ CYP1A2 P05177 1/20 0.56
▸ PTGS1 P23219 1/20 0.56
▸ SLC6A2 P23975 1/20 0.56
▸ CYP2C19 P33261 1/20 0.56
▸ PTGS2 P35354 1/20 0.56
▸ SLC6A3 Q01959 1/20 0.56
▸ HIF1A Q16665 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6948842 0.98 ALOX5 (0.60) ALOX5MAOBNR4A1NR4A2NR4A3
SCHEMBL13802503 0.94 RXRA (0.57) ALOX5PPARGPPARARXRARXRB
SCHEMBL8833698 0.90 ALOX5 (0.62) ALOX5MAOBNR4A1NR4A2NR4A3
SCHEMBL2170633 0.88 ALOX5 (0.67) ALOX5MAOBNR4A1NR4A2NR4A3
SCHEMBL9577464 0.88 ALOX5 (0.59) ALOX5MAOBNR4A1NR4A2NR4A3
SCHEMBL6948837 0.88 ALOX5 (0.59) ALOX5MAOBNR4A1NR4A2NR4A3
SCHEMBL9586230 0.87 AKR1C3 (0.70) ALOX5MAOBCYP1A2PTGS1PTGS2
SCHEMBL28353364 0.86 MRGPRX4 (0.59) ALOX5MAOBNR4A1NR4A2NR4A3
SCHEMBL6266373 0.86 LTA4H (0.59) ALOX5MAOBLMNAL3MBTL1ACACB
SCHEMBL14032970 0.86 KMT2A (0.59) ALOX5MAOBNR4A2PPARGPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10835520-B2 Phenyl derivative ONO PHARMACEUTICAL CO., LTD. (JP) 2020-11-17 — — US disclosed
US-20190030010-A1 PHENYL DERIVATIVE ONO PHARMACEUTICAL CO., LTD. (JP) 2019-01-31 — — US disclosed
US-10117861-B2 Phenyl derivative ONO PHARMACEUTICAL CO., LTD. (JP) 2018-11-06 — — US disclosed
EP-3150577-B1 PHENYL DERIVATIVE ONO PHARMACEUTICAL CO (JP) 2018-08-29 — — EP disclosed
US-20180042908-A1 PHENYL DERIVATIVE ONO PHARMACEUTICAL CO., LTD. (JP) 2018-02-15 — — US disclosed
US-9820980-B2 Phenyl derivative ONO PHARMACEUTICAL CO., LTD. (JP) 2017-11-21 — — US disclosed
EP-3150577-A1 PHENYL DERIVATIVE ONO PHARMACEUTICAL CO., LTD. (JP) 2017-04-05 — — EP disclosed
US-20160213660-A1 PHENYL DERIVATIVE ONO PHARMACEUTICAL CO., LTD. (JP) 2016-07-28 — — US disclosed
US-9340499-B2 Phenyl derivative ONO PHARMACEUTICAL CO., LTD. (JP) 2016-05-17 — — US disclosed
US-20150126486-A1 PHENYL DERIVATIVE ONO PHARMACEUTICAL CO., LTD. (JP) 2015-05-07 — — US disclosed
CN-1494425-A Carboxamide derivatives as therapeutic agents 特兰斯泰克制药公司 2004-05-05 — — CN disclosed
EP-1377295-A2 CARBOXAMIDE DERIVATIVES AS THERAPEUTIC AGENTS Transtech Pharma, Inc. (US) 2004-01-07 — — EP disclosed
US-20030236401-A1 Asymmetric synthesis of amino-pyrrolidinones BRISTOL-MYERS SQUIBB COMPANY 2003-12-25 — — US disclosed
WO-2003104220-A1 ASYMETRIC SYNTHESIS OF AMINO-PYRROLIDINONES BRISTOL-MYERS SQUIBB COMPANY (US) 2003-12-18 — — WO disclosed
US-20020193432-A1 Carboxamide derivatives as therapeutic agents VTVX HOLDINGS I LLC 2002-12-19 — — US disclosed
WO-2002070473-A2 CARBOXAMIDE DERIVATIVES AS THERAPEUTIC AGENTS TRANSTECH PHARMA, INC. (US) 2002-09-12 — — WO disclosed
EP-1165500-A1 AMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES,TNF-ALPHA,AND AGGRECANASE Du Pont Pharmaceuticals Company (US) 2002-01-02 — — EP disclosed
WO-2000059874-A1 NOVEL AMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES, TNF-α, AND AGGRECANASE DU PONT PHARMACEUTICALS COMPANY (US) 2000-10-12 — — WO disclosed
US-4560447-A Electrolytic process for preparation of α-alkylated acetic acid derivatives OTSUKA KAGAKU KABUSHIKI KAISHA (JP) 1985-12-24 — — US disclosed
EP-0008494-A1 Method of improving or maintaining digestibility of fodder crops IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1980-03-05 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10117861-B2 Phenyl derivative S1PR2, S1PR1, S1PR3 ALOX5 1260/4885MAOB 3182/4885NR4A1 704/4885
US-20150126486-A1 PHENYL DERIVATIVE S1PR2, S1PR1, S1PR3 ALOX5 1297/4885MAOB 3435/4885NR4A1 656/4885
US-20030236401-A1 Asymmetric synthesis of amino-pyrrolidinones ADAM17, EPRS1, ADAM8 ALOX5 3282/4885MAOB 1795/4885NR4A1 4588/4885
US-20180042908-A1 PHENYL DERIVATIVE S1PR2, S1PR1, S1PR3 ALOX5 1260/4885MAOB 3182/4885NR4A1 704/4885
US-20190030010-A1 PHENYL DERIVATIVE S1PR2, S1PR1, S1PR3 ALOX5 1260/4885MAOB 3182/4885NR4A1 704/4885
US-20160213660-A1 PHENYL DERIVATIVE S1PR2, S1PR1, S1PR3 ALOX5 1260/4885MAOB 3182/4885NR4A1 704/4885
US-20020193432-A1 Carboxamide derivatives as therapeutic agents AGER, S100B, S100A4 ALOX5 971/4885MAOB 2088/4885NR4A1 1462/4885
US-10835520-B2 Phenyl derivative S1PR2, S1PR1, S1PR3 ALOX5 1260/4885MAOB 3182/4885NR4A1 704/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.