Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 7/20 | 0.49 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | NMT1 | P30419 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2169824 | 0.90 | ESR1 (0.45) | HTR6LMNASMN1; SMN2ALDH1A1NMT1 | |
| SCHEMBL2170403 | 0.88 | HTR6 (0.50) | HTR6LIMK2CCNT1CDK9LMNA | |
| SCHEMBL2171757 | 0.87 | ESR1 (0.47) | LMNASMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL2170067 | 0.87 | CCNT1 (0.50) | HTR6LIMK2CCNT1CDK9LMNA | |
| Hydrochloric Acid SCHEMBL2169494 | 0.86 | CCNT1 (0.49) | HTR6LIMK2CCNT1CDK9LMNA | |
| SCHEMBL2173430 | 0.85 | HTR6 (0.48) | HTR6LMNASMN1; SMN2ALDH1A1HTT | |
| SCHEMBL2171321 | 0.84 | MEN1 (0.46) | HTR6LIMK2CCNT1CDK9LMNA | |
| SCHEMBL2169949 | 0.81 | ALDH1A1 (0.58) | HTR6LIMK2LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL2170359 | 0.81 | MAPT (0.48) | HTR6CCNT1CDK9LMNAMEN1 | |
| SCHEMBL2170956 | 0.79 | BRD4 (0.41) | HTR6CCNT1CDK9BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346847-A1 | ARYL SULFONAMIDE AMINE COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS | Suven Life Sciences Limited (IN) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010032258-A1 | ARYL SULFONAMIDE AMINE COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS | SUVEN LIFE SCIENCES LIMITED (IN) | 2010-03-25 | — | — | WO | disclosed |