Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 5/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.39 |
| ▸ | NMT1 | P30419 | 1/20 | 0.39 |
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2170768 | 0.90 | ESR1 (0.45) | MAPTNPSR1ESR1HTR6PGR | |
| SCHEMBL2170564 | 0.89 | HSD17B3 (0.48) | MAPTNPSR1ESR1HTR6LMNA | |
| SCHEMBL2170067 | 0.89 | CCNT1 (0.50) | MAPTHTR6PGRLMNACCNT1 | |
| SCHEMBL2171609 | 0.88 | HTR6 (0.46) | MAPTHTR6PGRLMNACCNT1 | |
| Hydrochloric Acid SCHEMBL2169494 | 0.88 | CCNT1 (0.49) | MAPTHTR6PGRLMNACCNT1 | |
| SCHEMBL2171331 | 0.84 | FFAR4 (0.48) | MAPTHTR6LMNAFFAR4 | |
| SCHEMBL2170956 | 0.83 | BRD4 (0.41) | MAPTHTR6CCNT1CDK9POLB | |
| SCHEMBL2170559 | 0.82 | SLC22A12 (0.47) | MAPTHTR6PGRLMNAMEN1 | |
| SCHEMBL2169824 | 0.82 | ESR1 (0.45) | MAPTESR1HTR6LMNAFFAR1 | |
| SCHEMBL2170726 | 0.81 | HTR6 (0.49) | HTR6LMNACCNT1CDK9MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346847-A1 | ARYL SULFONAMIDE AMINE COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS | Suven Life Sciences Limited (IN) | 2011-07-27 | — | — | EP | claimed |
| WO-2010032258-A1 | ARYL SULFONAMIDE AMINE COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS | SUVEN LIFE SCIENCES LIMITED (IN) | 2010-03-25 | — | — | WO | claimed |
| EP-2346847-A1 | ARYL SULFONAMIDE AMINE COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS | Suven Life Sciences Limited (IN) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010032258-A1 | ARYL SULFONAMIDE AMINE COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS | SUVEN LIFE SCIENCES LIMITED (IN) | 2010-03-25 | — | — | WO | disclosed |