Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM10 | O14672 | 12/20 | 0.58 |
| ▸ | ERBB2 | P04626 | 12/20 | 0.58 |
| ▸ | MMP2 | P08253 | 12/20 | 0.58 |
| ▸ | MMP9 | P14780 | 5/20 | 0.58 |
| ▸ | CTSK | P43235 | 4/20 | 0.46 |
| ▸ | CTSB | P07858 | 3/20 | 0.46 |
| ▸ | CTSS | P25774 | 3/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2171999 | 1.00 | ADAM10 (0.58) | ADAM10ERBB2MMP2MMP9CTSK | |
| SCHEMBL2172398 | 0.92 | ADAM10 (0.60) | ADAM10ERBB2MMP2MMP9CTSK | |
| SCHEMBL2172391 | 0.92 | ADAM10 (0.60) | ADAM10ERBB2MMP2MMP9CTSK | |
| SCHEMBL2174658 | 0.87 | ADAM10 (0.75) | ADAM10ERBB2MMP2MMP9CTSK | |
| SCHEMBL2171483 | 0.74 | ADAM10 (0.68) | ADAM10ERBB2MMP2MMP9CTSK | |
| SCHEMBL2172915 | 0.73 | ADAM10 (1.00) | ADAM10ERBB2MMP2MMP9CTSK | |
| SCHEMBL3468338 | 0.73 | ADAM10 (1.00) | ADAM10ERBB2MMP2MMP9CTSK | |
| SCHEMBL3457594 | 0.73 | ADAM10 (0.64) | ADAM10ERBB2MMP2MMP9CTSK | |
| SCHEMBL3457591 | 0.73 | ADAM10 (0.64) | ADAM10ERBB2MMP2MMP9CTSK | |
| SCHEMBL2171702 | 0.73 | ADAM10 (0.64) | ADAM10ERBB2MMP2MMP9CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8853243-B2 | Substituted cyclic hydroxamates as inhibitors of matrix metalloproteinases | INCYTE CORPORATION (US) | 2014-10-07 | — | — | US | disclosed |
| US-20110224189-A1 | SUBSTITUTED CYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES | INCYTE CORPORATION | 2011-09-15 | — | — | US | disclosed |
| US-7973041-B2 | Antiarthritic agents; psoriasis; anticancer agents;antiallergens; metalloprotease inhibitors. | INCYTE CORPORATION (US) | 2011-07-05 | — | — | US | disclosed |
| US-20080167288-A1 | Substituted cyclic hydroxamates as lnhibitors of matrix metalloproteinases | LNCYTE CORPORATION (US) | 2008-07-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110224189-A1 | SUBSTITUTED CYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES | MMP25, MMP14, MMP9 | ADAM10 25/4885ERBB2 2986/4885MMP2 4/4885 |
| US-20080167288-A1 | Substituted cyclic hydroxamates as lnhibitors of matrix metalloproteinases | MMP25, MMP9, MMP24 | ADAM10 25/4885ERBB2 3033/4885MMP2 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.