Hydrochloric Acid

Hydrochloric Acid

SCHEMBL217236

CC1=C2CCC3=C(C)C([Hf+2]C1c1cccc(-c4ccccc4)c12)c1cccc(-c2ccccc2)c13.[Cl-].[Cl-]

nearest known ligand 0.35

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PARP10 Q53GL7 2/20 0.35
PARP11 Q9NR21 2/20 0.35
HTR1A P08908 4/20 0.34
HTR7 P34969 4/20 0.34
DRD2 P14416 1/20 0.34
CHRNB2 P17787 1/20 0.33
CHRNA4 P43681 1/20 0.33
CYP11B2 P19099 3/20 0.32
BRD4 O60885 1/20 0.32
CYP17A1 P05093 1/20 0.32
CYP19A1 P11511 1/20 0.32
CYP11B1 P15538 1/20 0.32
PDCD1 Q15116 1/20 0.32
CD274 Q9NZQ7 1/20 0.32
ADRA2A P08913 3/20 0.31
ADRA2B P18089 2/20 0.31
ADRA2C P18825 2/20 0.31
HTR2B P41595 1/20 0.30
TMEM97 Q5BJF2 1/20 0.30
SIGMAR1 Q99720 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL219025 0.91 CHRNB2 (0.33) PARP10PARP11HTR1AHTR7DRD2
Hydrochloric Acid SCHEMBL5616232 0.79 HTR1A (0.34) PARP10PARP11HTR1AHTR7DRD2
Hydrochloric Acid SCHEMBL217523 0.79 HTR1A (0.36) PARP10PARP11HTR1AHTR7DRD2
Hydrochloric Acid SCHEMBL218502 0.79 ADRA2C (0.33) CYP11B2CYP17A1CYP19A1CYP11B1ADRA2C
Hydrochloric Acid SCHEMBL7583888 0.78 PDCD1 (0.31) CHRNB2CHRNA4PDCD1CD274
SCHEMBL3672615 0.78 HTR1A (0.35) PARP10PARP11HTR1AHTR7DRD2
SCHEMBL7599331 0.77 HTR1A (0.34) HTR1AHTR7DRD2CHRNB2CHRNA4
SCHEMBL5345743 0.77 HTR1A (0.34) HTR1AHTR7DRD2CHRNB2CHRNA4
Hydrochloric Acid SCHEMBL218411 0.73 GPR3 (0.31)
SCHEMBL5354721 0.72 HTR1A (0.33) HTR1AHTR7DRD2CHRNB2CHRNA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8088867-B2 Multiple catalyst system for olefin polymerization and polymers produced therefrom EXXONMOBIL CHEMICAL PATENTS INC. (US) 2012-01-03 US claimed
EP-1558655-B1 MULTIPLE CATALYST SYSTEM FOR OLEFIN POLYMERIZATION AND POLYMERS PRODUCED THEREFROM EXXONMOBIL CHEM PATENTS INC (US) 2012-08-29 EP disclosed
US-8088867-B2 Multiple catalyst system for olefin polymerization and polymers produced therefrom EXXONMOBIL CHEMICAL PATENTS INC. (US) 2012-01-03 US disclosed
US-7662895-B2 comprising polypropylene which is produced in presence of a metallocene transition metal catalyst and an activator; peak melting point temperature below about 110 degrees C., a tensile set of 40% or less, and greater than or equal to about 60% [r]dyads EXXONMOBIL CHEMICAL PATENTS INC. (US) 2010-02-16 US disclosed
US-20070117941-A1 Syndiotactic propylene elastomers EXXONMOBIL CHEMICAL PATENTS INC. 2007-05-24 US disclosed
EP-1753796-A1 MULTIPLE CATALYST AND REACTOR SYSTEM FOR OLEFIN POLYMERIZATION AND POLYMERS PRODUCED THEREFROM ExxonMobil Chemical Patents, Inc., A Corporation of the State of Delaware (US) 2007-02-21 EP disclosed
WO-2005113622-A1 MULTIPLE CATALYST AND REACTOR SYSTEM FOR OLEFIN POLYMERIZATION AND POLYMERS PRODUCED THEREFROM EXXONMOBIL CHEMICAL PATENTS INC. (US) 2005-12-01 WO disclosed
EP-1558655-A2 MULTIPLE CATALYST SYSTEM FOR OLEFIN POLYMERIZATION AND POLYMERS PRODUCED THEREFROM Exxonmobil Chemical Patents Inc. (US) 2005-08-03 EP disclosed
WO-2004046214-A2 MULTIPLE CATALYST SYSTEM FOR OLEFIN POLYMERIZATION AND POLYMERS PRODUCED THEREFROM EXXONMOBIL CHEMICAL PATENTS INC. (US) 2004-06-03 WO disclosed