Sugi Predict

Sugi Predict / Compounds / SCHEMBL21723957

SCHEMBL21723957

SCHEMBL21723957

CCN(CC)c1ccc(-c2cc3c(s2)c(-c2cccs2)cc(=O)n3C)cc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ BACE1 P56817 1/20 0.39
▸ NR3C1 P04150 1/20 0.38
▸ PGR P06401 1/20 0.38
▸ AR P10275 1/20 0.38
▸ MAPT P10636 6/20 0.37
▸ KDM4E B2RXH2 1/20 0.34
▸ PKM P14618 1/20 0.34
▸ MEN1 O00255 6/20 0.34
▸ KMT2A Q03164 6/20 0.34
▸ ALDH1A1 P00352 6/20 0.34
▸ MAPK1 P28482 3/20 0.34
▸ L3MBTL1 Q9Y468 3/20 0.34
▸ HPGD P15428 2/20 0.34
▸ HSD17B10 Q99714 2/20 0.34
▸ GAA P10253 2/20 0.33
▸ RAB9A P51151 2/20 0.33
▸ GABRA1 P14867 1/20 0.33
▸ GABRG2 P18507 1/20 0.33
▸ GABRB3 P28472 1/20 0.33
▸ GABRA5 P31644 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21723978 0.86 HSD17B10 (0.44) MAPTKDM4EPKMMEN1KMT2A
SCHEMBL27217472 0.83 ESR1 (0.35) MAPTKDM4EMEN1KMT2AALDH1A1
SCHEMBL21723952 0.81 GSK3B (0.41) MAPTKDM4EPKMMEN1KMT2A
SCHEMBL21723917 0.81 ALDH1A1 (0.38) MAPTKDM4EMEN1KMT2AALDH1A1
SCHEMBL21723630 0.81 GSK3B (0.38) BACE1MAPTKDM4EMEN1KMT2A
SCHEMBL21723905 0.80 PGR (0.39) PGRMAPTKDM4EMEN1KMT2A
SCHEMBL21723927 0.80 RARB (0.44) MAPTPKMMEN1KMT2AALDH1A1
SCHEMBL21723837 0.78 MAPT (0.36) MAPTKDM4EPKMMEN1KMT2A
SCHEMBL23451965 0.77 ALDH1A1 (0.38) MAPTKDM4EPKMMEN1KMT2A
SCHEMBL23452121 0.74 MAPT (0.37) MAPTKDM4EMEN1KMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12415813-B2 Method for synthesizing thieno[3,2-b]pyridine-5(4H)-one derivative compound, using gold catalyst, and use therefor KOREA INSTITUTE OF OCEAN SCIENCE & TECHNOLOGY (KR) 2025-09-16 — — US disclosed
US-20210332063-A1 METHOD FOR SYNTHESIZING THIENO[3,2-B]PYRIDINE-5(4H)-ONE DERIVATIVE COMPOUND, USING GOLD CATALYST, AND USE THEREFOR KOREA INSTITUTE OF OCEAN SCIENCE & TECHNOLOGY (KP) 2021-10-28 — — US disclosed
US-20210332063-A1 METHOD FOR SYNTHESIZING THIENO[3,2-B]PYRIDINE-5(4H)-ONE DERIVATIVE COMPOUND, USING GOLD CATALYST, AND USE THEREFOR KOREA INSTITUTE OF OCEAN SCIENCE & TECHNOLOGY (KP) 2021-10-28 — — US disclosed
WO-2020036243-A1 METHOD FOR SYNTHESIZING THIENO[3,2-B]PYRIDINE-5(4H)-ONE DERIVATIVE COMPOUND, USING GOLD CATALYST, AND USE THEREFOR 한국해양과학기술원 2020-02-20 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210332063-A1 METHOD FOR SYNTHESIZING THIENO[3,2-B]PYRIDINE-5(4H)-ONE DERIVATIVE COMPOUND, USING GOLD CATALYST, AND USE THEREFOR FARS2, CYP4F11, CYP4B1 BACE1 1817/4885NR3C1 3834/4885PGR 1582/4885
US-12415813-B2 Method for synthesizing thieno[3,2-b]pyridine-5(4H)-one derivative compound, using gold catalyst, and use therefor FARS2, CYP4F11, CYP4B1 BACE1 1817/4885NR3C1 3834/4885PGR 1582/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.