Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | RAB9A | P51151 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.61 |
| ▸ | HTT | P42858 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17470589 | 1.00 | ALDH1A1 (0.66) | ALDH1A1KMT2ARAB9AMEN1SMN1; SMN2 | |
| SCHEMBL522134 | 1.00 | ALDH1A1 (0.66) | ALDH1A1KMT2ARAB9AMEN1SMN1; SMN2 | |
| SCHEMBL20022939 | 0.87 | ALDH1A1 (0.56) | ALDH1A1KMT2ARAB9AMEN1SMN1; SMN2 | |
| SCHEMBL5862604 | 0.84 | ALDH1A1 (0.72) | ALDH1A1KMT2ARAB9AMEN1SMN1; SMN2 | |
| SCHEMBL14344292 | 0.83 | ALDH1A1 (0.84) | ALDH1A1KMT2ARAB9AMEN1SMN1; SMN2 | |
| SCHEMBL10022041 | 0.83 | ALDH1A1 (0.70) | ALDH1A1KMT2ARAB9AMEN1SMN1; SMN2 | |
| SCHEMBL13528565 | 0.83 | ALDH1A1 (0.84) | ALDH1A1KMT2ARAB9AMEN1SMN1; SMN2 | |
| SCHEMBL11529889 | 0.81 | ALDH1A1 (0.79) | ALDH1A1KMT2ARAB9AMEN1SMN1; SMN2 | |
| SCHEMBL11594277 | 0.80 | ALDH1A1 (0.83) | ALDH1A1KMT2ARAB9AMEN1SMN1; SMN2 | |
| SCHEMBL28513627 | 0.80 | ALDH1A1 (0.56) | ALDH1A1KMT2ARAB9AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210386861-A1 | BRUSH PRODRUGS AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2021-12-16 | — | — | US | disclosed |
| US-10988491-B2 | Degradable polymers of a cyclic silyl ether and uses thereof | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2021-04-27 | — | — | US | disclosed |
| US-20200055879-A1 | DEGRADABLE POLYMERS OF A CYCLIC SILYL ETHER AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2020-02-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210386861-A1 | BRUSH PRODRUGS AND USES THEREOF | ABCB11, SI, ABCB1 | ALDH1A1 789/4885KMT2A 2639/4885RAB9A 2169/4885 |
| US-20200055879-A1 | DEGRADABLE POLYMERS OF A CYCLIC SILYL ETHER AND USES THEREOF | SI, ILK, PCNA | ALDH1A1 2604/4885KMT2A 2882/4885RAB9A 3208/4885 |
| US-10988491-B2 | Degradable polymers of a cyclic silyl ether and uses thereof | SI, ILK, PCNA | ALDH1A1 2604/4885KMT2A 2882/4885RAB9A 3208/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.