Sugi Predict

Sugi Predict / Compounds / SCHEMBL2173254

SCHEMBL2173254

SCHEMBL2173254

Cn1ccc(S(N)(=O)=O)n1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KEAP1 Q14145 1/20 0.39
▸ KMT2A Q03164 1/20 0.38
▸ NLRP3 Q96P20 1/20 0.38
▸ CA12 O43570 4/20 0.37
▸ CA1 P00915 4/20 0.37
▸ CA2 P00918 4/20 0.37
▸ CA9 Q16790 4/20 0.37
▸ CA6 P23280 3/20 0.36
▸ CA5A P35218 3/20 0.36
▸ CA7 P43166 3/20 0.36
▸ CA4 P22748 2/20 0.36
▸ CA14 Q9ULX7 2/20 0.36
▸ CA13 Q8N1Q1 1/20 0.36
▸ CA5B Q9Y2D0 2/20 0.33
▸ SMN1; SMN2 Q16637 2/20 0.33
▸ KDM4E B2RXH2 1/20 0.33
▸ ALDH1A1 P00352 1/20 0.33
▸ LMNA P02545 1/20 0.33
▸ HTT P42858 1/20 0.33
▸ CCR2 P41597 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31442338 0.83 KEAP1 (0.37) KEAP1KMT2ANLRP3CA12CA1
SCHEMBL2606651 0.80 KMT2A (0.39) KEAP1KMT2ANLRP3SMN1; SMN2KDM4E
SCHEMBL20552 0.78 KMT2A (0.38) KEAP1KMT2ANLRP3SMN1; SMN2KDM4E
Hydrochloric Acid SCHEMBL27668438 0.77 NLRP3 (0.40) KEAP1KMT2ANLRP3SMN1; SMN2KDM4E
SCHEMBL22871837 0.75 L3MBTL1 (0.38) KEAP1KMT2ANLRP3SMN1; SMN2KDM4E
SCHEMBL19913402 0.75 NLRP3 (0.36) KEAP1KMT2ANLRP3SMN1; SMN2KDM4E
SCHEMBL15473846 0.75 NLRP3 (0.48) KEAP1KMT2ANLRP3CA12CA1
SCHEMBL21583704 0.75 CA2 (0.34) CA12CA1CA2CA9CA6
SCHEMBL22942881 0.75 KMT2A (0.41) KEAP1KMT2ANLRP3SMN1; SMN2KDM4E
SCHEMBL12000925 0.74 NLRP3 (0.47) KMT2ANLRP3CA1CA2SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 80 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250388568-A1 NLRP3 INHIBITORS KODIAK SCIENCES INC (US) 2025-12-25 — — US disclosed
US-12187742-B2 Dual ATM and DNA-PK inhibitors for use in anti-tumor therapy XRAD THERAPEUTICS, INC. (US) 2025-01-07 — — US disclosed
US-20240400502-A1 SULFONYLUREAS AND RELATED COMPOUNDS AND USE OF SAME UNIV QUEENSLAND (AU) 2024-12-05 — — US disclosed
CN-118852135-A N-acyl sulfonamide compound, preparation method, pharmaceutical composition and application thereof 中国医学科学院药物研究所 2024-10-29 — — CN disclosed
CN-113582889-B Sulfonylureas and related compounds and uses thereof 昆士兰大学 2024-09-20 — — CN disclosed
EP-3416948-B1 INDACENE BEARING SULFONYLUREAS AS ANTI-INFLAMMATORY AGENTS UNIV QUEENSLAND (AU) 2024-07-24 — — EP disclosed
CN-117956992-A MENIN-MLL interaction inhibitors 赛达克斯制药股份有限公司 2024-04-30 — — CN disclosed
US-11919901-B2 Inhibitors of the menin-MLL interaction SYNDAX PHARMACEUTICALS, INC. (US) 2024-03-05 — — US disclosed
US-11858922-B2 Sulfonylureas and related compounds and use of same THE UNIVERSITY OF QUEENSLAND (AU) 2024-01-02 — — US disclosed
US-11845715-B2 — — 2023-12-19 — — US disclosed
WO-2011082270-A2 SUBSTITUTED IMIDAZOPYRIDINYL-AMINOPYRIDINE COMPOUNDS ARQULE. INC. (US) 2011-07-07 — — WO disclosed
WO-2011025982-A2 TETRACYCLINE COMPOUNDS TETRAPHASE PHARMACEUTICALS, INC. (US) 2011-03-03 — — WO disclosed
EP-0087780-B2 Pyrazolesulfonylurea derivative, preparation thereof, herbicide containing said derivative as active ingredient and herbicidal method by use thereof NISSAN CHEMICAL IND LTD (JP) 1995-02-15 — — EP disclosed
EP-0095925-B2 Herbicidal imidazole, pyrazole, thiazole and isothiazole derivatives DU PONT (US) 1994-12-07 — — EP disclosed
US-4954164-A Pyrazolesulfonylurea derivatives, preparation thereof, herbicide containing said derivative as active ingredient and herbicidal method by use thereof NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 1990-09-04 — — US disclosed
US-4946496-A PLANT GROWTH REGULATORS E. I. DU PONT DE NEMOURS AND COMPANY (US) 1990-08-07 — — US disclosed
US-4931081-A Herbicidal diazoles sulfonamides E. I. DU PONT DE NEMOURS AND COMPANY (US) 1990-06-05 — — US disclosed
EP-0095925-B1 HERBICIDAL IMIDAZOLE, PYRAZOLE, THIAZOLE AND ISOTHIAZOLE DERIVATIVES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1989-03-22 — — EP disclosed
EP-0095925-A2 Herbicidal imidazole, pyrazole, thiazole and isothiazole derivatives E.I. DU PONT DE NEMOURS AND COMPANY (US) 1983-12-07 — — EP disclosed
EP-0087780-A2 Pyrazolesulfonylurea derivative, preparation thereof, herbicide containing said derivative as active ingredient and herbicidal method by use thereof NISSAN CHEMICAL INDUSTRIES LTD. (JP) 1983-09-07 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11845715-B2 — NLRP3, PYCARD, NOD1 KEAP1 190/4885KMT2A 4317/4885NLRP3 1/4885
US-11919901-B2 Inhibitors of the menin-MLL interaction MLLT1, MEN1, MLLT3 KEAP1 1214/4885KMT2A 12/4885NLRP3 2981/4885
US-20240400502-A1 SULFONYLUREAS AND RELATED COMPOUNDS AND USE OF SAME NLRP3, PYCARD, IAPP KEAP1 637/4885KMT2A 4072/4885NLRP3 1/4885
US-11858922-B2 Sulfonylureas and related compounds and use of same NLRP3, NOD1, PYCARD KEAP1 542/4885KMT2A 3753/4885NLRP3 1/4885
US-20250388568-A1 NLRP3 INHIBITORS NLRP3, NOD1, NLRP1 KEAP1 30/4885KMT2A 4514/4885NLRP3 1/4885
US-12187742-B2 Dual ATM and DNA-PK inhibitors for use in anti-tumor therapy ATM, CHEK2, CHEK1 KEAP1 1063/4885KMT2A 918/4885NLRP3 4673/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.