Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 5/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | PARP1 | P09874 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2171096 | 0.90 | SCN9A (0.51) | SCN9AHPGDMEN1KMT2AALDH1A1 | |
| SCHEMBL2170398 | 0.87 | ALDH1A1 (0.51) | SCN9AALDH1A1KDM4E | |
| SCHEMBL2185323 | 0.84 | SCN9A (0.45) | SCN9AHPGDMEN1KMT2A | |
| SCHEMBL2171621 | 0.83 | QRFPR (0.50) | SCN9AALDH1A1 | |
| SCHEMBL2169808 | 0.83 | SCN9A (0.48) | SCN9AALDH1A1 | |
| SCHEMBL2171851 | 0.83 | KMT2A (0.53) | SCN9AHPGDKMT2AALDH1A1 | |
| SCHEMBL2170108 | 0.82 | LMNA (0.52) | SCN9AMEN1KMT2AALDH1A1PARP1 | |
| SCHEMBL2350905 | 0.82 | HPGD (0.48) | SCN9AHPGDMEN1KMT2AHRH3 | |
| SCHEMBL2169958 | 0.82 | SCN9A (0.47) | SCN9AMEN1KMT2AHRH3ALDH1A1 | |
| SCHEMBL2170146 | 0.80 | SCN9A (0.48) | SCN9AMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346821-A1 | SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS | Exelixis, Inc. (US) | 2011-07-27 | — | — | EP | disclosed |