Malonic Acid

Malonic Acid

SCHEMBL2174031

NC1CCCCC1N.O=C([O-])CC(=O)[O-].[Pt+2]

nearest known ligand 0.48

Full drug profile on Sugi Atlas →

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CA4 P22748 2/20 0.48
THRB P10828 1/20 0.48
MEN1 O00255 1/20 0.48
KMT2A Q03164 1/20 0.48
MMP2 P08253 4/20 0.42
CA12 O43570 4/20 0.42
CA1 P00915 4/20 0.42
CA2 P00918 4/20 0.42
CA9 Q16790 4/20 0.42
MMP1 P03956 4/20 0.42
MMP9 P14780 3/20 0.42
MMP8 P22894 3/20 0.42
MMP3 P08254 2/20 0.42
MMP13 P45452 1/20 0.42
ANPEP P15144 3/20 0.42
ERAP2 Q6P179 3/20 0.42
BBOX1 O75936 2/20 0.33
SMN1; SMN2 Q16637 1/20 0.31
EPHX1 P07099 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acetoacetic Acid SCHEMBL9689813 0.87 THRB (0.40) CA4THRBMEN1KMT2AMMP2
Oxalic Acid SCHEMBL29422639 0.82 MEN1 (0.56) CA4THRBMEN1KMT2AMMP2
Oxalic Acid SCHEMBL965059 0.82 MEN1 (0.56) CA4THRBMEN1KMT2AMMP2
Oxalic Acid SCHEMBL4859 0.82 MEN1 (0.56) CA4THRBMEN1KMT2AMMP2
Oxalic Acid SCHEMBL28195348 0.80 MEN1 (0.53) CA4THRBMEN1KMT2AMMP2
Oxalic Acid SCHEMBL28517984 0.80 MEN1 (0.53) CA4THRBMEN1KMT2AMMP2
Oxalic Acid SCHEMBL28020190 0.80 MEN1 (0.53) CA4THRBMEN1KMT2AMMP2
Oxalic Acid SCHEMBL28173309 0.80 MEN1 (0.53) CA4THRBMEN1KMT2AMMP2
Fosfonet SCHEMBL9687545 0.79 MMP2 (0.42) THRBMEN1KMT2AMMP2CA12
Oxalic Acid SCHEMBL29186473 0.77 THRB (0.43) THRBMEN1KMT2AMMP2CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20020193434-A1 Anti-tumor composition AJINOMOTO CO. INC (JP) 2002-12-19 US claimed
US-20020193362-A1 Anti-tumor composition AJINOMOTO CO. INC (JP) 2002-12-19 US claimed
CN-119751480-A Thiocarbamate derivatives as A2A inhibitors, pharmaceutical compositions thereof, and combinations with anticancer agents ITEOS比利时公司 2025-04-04 CN disclosed
CN-119486755-A DLK1 antibodies and methods of treating cancer 加利福尼亚大学校董会 2025-02-18 CN disclosed
CN-113226324-B Thiocarbamate derivatives as A2A inhibitors, pharmaceutical compositions thereof, and combinations with anticancer agents ITEOS比利时公司 2024-12-31 CN disclosed
CN-119212721-A CDH17 antibodies and methods of treating cancer 加利福尼亚大学校董会 2024-12-27 CN disclosed
CN-117136242-A Compounds, compositions and methods of treatment thereof ITEOS比利时公司 2023-11-28 CN disclosed
CN-116570628-A Clostridium northwest for treating solid tumors in humans 生物医学谷探索股份有限公司 2023-08-11 CN disclosed
CN-116410318-A anti-AXL antagonistic antibodies 卑尔根技术锻造股份公司 2023-07-11 CN disclosed
CN-105451750-B Clostridium noeukii for the treatment of solid tumors in humans 生物医学谷探索股份有限公司 2023-03-10 CN disclosed
CN-107531786-B anti-AXL antagonist antibodies 卑尔根技术锻造股份公司(NO) 2023-01-13 CN disclosed
US-7655696-B2 Highly efficacious and highly safe composition of a Stilbene derivative and a platinum coordination compound cis-diaminedichloroplatinum (II) AJINOMOTO CO., INC. (JP) 2010-02-02 US disclosed
US-20090093540-A1 ANTI-TUMOR COMPOSITION AJINOMOTO CO., INC. (JP) 2009-04-09 US disclosed
EP-1068870-B1 ANTITUMOR AGENTS AJINOMOTO KK (JP) 2006-06-07 EP disclosed
US-6992106-B2 Anti-tumor composition AJINOMOTO CO., INC. (JP) 2006-01-31 US disclosed
US-20050281892-A1 Highly efficacious and highly safe composition of a Stilbene derivative and a platinum coordination compound cis-diaminedichloroplatinum (II) AJINOMOTO CO., INC. (JP) 2005-12-22 US disclosed
US-20020193434-A1 Anti-tumor composition AJINOMOTO CO. INC (JP) 2002-12-19 US disclosed
US-20020193362-A1 Anti-tumor composition AJINOMOTO CO. INC (JP) 2002-12-19 US disclosed
US-6462087-B1 Anti-tumor composition AJINOMOTO CO., INC. (JP) 2002-10-08 US disclosed
EP-1068870-A1 ANTITUMOR AGENTS Ajinomoto Co., Inc. (JP) 2001-01-17 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020193434-A1 Anti-tumor composition TP53, VHL, MKI67 CA4 162/4885THRB 2902/4885MEN1 908/4885
US-20050281892-A1 Highly efficacious and highly safe composition of a Stilbene derivative and a platinum coordination compound cis-diaminedichloroplatinum (II) MSH2, TOP2B, TP53 CA4 1079/4885THRB 3940/4885MEN1 212/4885
US-20020193362-A1 Anti-tumor composition TP53, VHL, MKI67 CA4 162/4885THRB 2902/4885MEN1 908/4885
US-20090093540-A1 ANTI-TUMOR COMPOSITION TP53, VHL, MKI67 CA4 184/4885THRB 2922/4885MEN1 873/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.