Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | PNP | P00491 | 11/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | AHCY | P23526 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7617790 | 0.87 | PNP (0.36) | ADORA2AADORA2BPNP | |
| SCHEMBL601906 | 0.84 | PNP (0.34) | ADORA2AADORA2BPNP | |
| SCHEMBL5503490 | 0.82 | ADORA2A (0.49) | ADORA2AADORA2BADORA1PNPSMN1; SMN2 | |
| SCHEMBL9960806 | 0.80 | PNP (0.38) | ADORA2AADORA2BPNPLMNA | |
| SCHEMBL7173171 | 0.79 | ADORA2A (0.40) | ADORA2AADORA2BADORA1PNP | |
| SCHEMBL16106177 | 0.79 | ADORA2A (0.37) | ADORA2AADORA2BADORA1LMNA | |
| SCHEMBL6464905 | 0.78 | PNP (0.35) | ADORA2AADORA2BPNPLMNA | |
| SCHEMBL874734 | 0.77 | ADORA2A (0.45) | ADORA2AADORA2BPNP | |
| SCHEMBL2113436 | 0.77 | ADORA2A (0.33) | ADORA2AADORA2BADORA1PNP | |
| SCHEMBL5048171 | 0.77 | PNP (0.39) | ADORA2BPNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3693463-A1 | COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE ALAS1 GENE | Alnylam Pharmaceuticals, Inc. (US) | 2020-08-12 | — | — | EP | disclosed |
| EP-3052628-B1 | COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE ALAS1 GENE | ALNYLAM PHARMACEUTICALS INC (US) | 2020-02-26 | — | — | EP | disclosed |