SCHEMBL21751347

SCHEMBL21751347

COCc1cccc(Cc2nc3c(Cc4ccccc4)[nH]c(-c4cccc(O[Si](C)(C)C(C)(C)C)c4)cn-3c2=O)c1

nearest known ligand 0.34

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ MAOA P21397 1/20 0.34
▸ PREP P48147 1/20 0.33
▸ LTB4R Q15722 1/20 0.33
▸ POLB P06746 1/20 0.32
▸ KMT2A Q03164 2/20 0.32
▸ ALDH1A1 P00352 1/20 0.32
▸ HPGD P15428 1/20 0.32
▸ XBP1 P17861 1/20 0.32
▸ NPSR1 Q6W5P4 1/20 0.32
▸ SLC16A3 O15427 2/20 0.31
▸ SLC16A1 P53985 2/20 0.31
▸ MCTS1 Q9ULC4 2/20 0.31
▸ PTGS2 P35354 1/20 0.31
▸ MEN1 O00255 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21751381 0.94 MAOA (0.38) MAOALTB4RKMT2AALDH1A1HPGD
SCHEMBL30514739 0.94 MAOA (0.38) MAOALTB4RKMT2AALDH1A1HPGD
SCHEMBL30800137 0.93 LTB4R (0.40) MAOALTB4RKMT2AALDH1A1HPGD
SCHEMBL21751395 0.93 LTB4R (0.40) MAOALTB4RKMT2AALDH1A1HPGD
SCHEMBL21751418 0.91 SMN1; SMN2 (0.39) MAOALTB4RKMT2AALDH1A1HPGD
SCHEMBL30800205 0.91 SMN1; SMN2 (0.39) MAOALTB4RKMT2AALDH1A1HPGD
SCHEMBL21751333 0.89 MAOA (0.35) MAOAKMT2AALDH1A1HPGDXBP1
SCHEMBL19206693 0.88 POLB (0.38) MAOALTB4RPOLBKMT2AALDH1A1
SCHEMBL21767317 0.88 MAOA (0.36) MAOAALDH1A1HPGD
SCHEMBL21751400 0.87 MAOA (0.35) MAOAKMT2AALDH1A1HPGDXBP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3981839-B1 COELENTERAZINE ANALOGS FOR USE IN LUCIFERASE-BASED ASSAYS PROMEGA CORP (US) 2025-08-20 — — EP disclosed
US-20240059697-A1 COELENTERAZINE ANALOGUES PROMEGA CORPORATION 2024-02-22 — — US disclosed
US-11691976-B2 Coelenterazine analogues PROMEGA CORPORATION (US) 2023-07-04 — — US disclosed
US-11691976-B2 Coelenterazine analogues PROMEGA CORPORATION (US) 2023-07-04 — — US disclosed
EP-3841173-A1 COELENTERAZINE ANALOGUES Promega Corporation (US) 2021-06-30 — — EP disclosed
US-20200062766-A1 COELENTERAZINE ANALOGUES PROMEGA CORPORATION 2020-02-27 — — US disclosed
US-20200062766-A1 COELENTERAZINE ANALOGUES PROMEGA CORPORATION 2020-02-27 — — US disclosed
WO-2020041579-A1 COELENTERAZINE ANALOGUES PROMEGA CORPORATION (US) 2020-02-27 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200062766-A1 COELENTERAZINE ANALOGUES GLB1, SI, TCF7L2 MAOA 3004/4885PREP 515/4885LTB4R 3143/4885
US-11691976-B2 Coelenterazine analogues GLB1, SI, TCF7L2 MAOA 3004/4885PREP 515/4885LTB4R 3143/4885
US-20240059697-A1 COELENTERAZINE ANALOGUES GLB1, SI, TCF7L2 MAOA 3004/4885PREP 515/4885LTB4R 3143/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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