SCHEMBL21753694

SCHEMBL21753694

NC(=O)C(C(N)=O)c1ccccc1N

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 2/20 0.41
CYP3A4 P08684 2/20 0.41
CASP1 P29466 1/20 0.41
CASP7 P55210 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
MAPT P10636 2/20 0.39
GAA P10253 2/20 0.39
TSHR P16473 2/20 0.39
CA1 P00915 1/20 0.39
CA2 P00918 1/20 0.39
CA9 Q16790 1/20 0.39
HSD17B10 Q99714 3/20 0.38
ALDH1A1 P00352 3/20 0.38
CFTR P13569 1/20 0.38
L3MBTL1 Q9Y468 2/20 0.37
POLB P06746 1/20 0.37
PARP1 P09874 1/20 0.37
CYP2C19 P33261 1/20 0.37
RECQL P46063 1/20 0.37
BLM P54132 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2208871 0.84 SRC (0.50) ALOX15CYP3A4CASP1CASP7SMN1; SMN2
SCHEMBL22082552 0.82 CA1 (0.40) ALOX15CYP3A4CASP1CASP7SMN1; SMN2
SCHEMBL22082554 0.82 CA1 (0.40) ALOX15CYP3A4CASP1CASP7SMN1; SMN2
SCHEMBL22081846 0.82 CA1 (0.40) ALOX15CYP3A4CASP1CASP7SMN1; SMN2
SCHEMBL250282 0.80 CXCL8 (0.49) ALOX15CYP3A4CASP1CASP7SMN1; SMN2
SCHEMBL9884404 0.77 CA1 (0.34) ALOX15CYP3A4CASP1CASP7SMN1; SMN2
SCHEMBL29032083 0.77 CTSD (0.46) SMN1; SMN2GAAALDH1A1L3MBTL1POLB
SCHEMBL28996258 0.77 ALDH1A1 (0.56) TSHRHSD17B10ALDH1A1CFTRTDP1
SCHEMBL11515089 0.76 ALOX15 (0.35) ALOX15MAPTTSHRCA1CA2
SCHEMBL12651209 0.76 CYP2C19 (0.36) ALOX15CYP3A4CASP1CASP7SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116903581-A SHP2/HDAC double-target inhibitor and preparation method and application thereof 山东大学 2023-10-20 CN claimed
CN-112533967-B Oil-in-water droplet type emulsion of active energy ray-curable resin composition and thermosensitive recording material 日本化药株式会社 2023-09-15 CN disclosed
CN-112533967-A Oil-in-water emulsion of active energy ray-curable resin composition and thermal recording material 日本化药株式会社 2021-03-19 CN disclosed
WO-2020039601-A1 OIL-IN-WATER TYPE EMULSION OF ACTINIC-RAY-CURABLE RESIN COMPOSITION, AND THERMAL RECORDING MATERIAL 日本化薬株式会社 2020-02-27 WO disclosed