Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 6/20 | 0.54 |
| ▸ | HTR6 | P50406 | 1/20 | 0.51 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.49 |
| ▸ | CHRNG | P07510 | 1/20 | 0.49 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.49 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.49 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.49 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.49 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.49 |
| ▸ | CHRND | Q07001 | 1/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | FASN | P49327 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16954663 | 0.90 | CYP11B2 (0.50) | HTR2CHTR6CHRNA1CHRNGCHRNB1 | |
| SCHEMBL10088668 | 0.86 | CYP11B2 (0.49) | HTR6CHRNA1CHRNGCHRNB1CHRNB2 | |
| SCHEMBL14290362 | 0.86 | CYP11B2 (0.49) | CHRNA1CHRNGCHRNB1CHRNB2CHRNB4 | |
| SCHEMBL30963 | 0.83 | CYP11B2 (0.46) | HTR2CHTR6CHRNA1CHRNGCHRNB1 | |
| SCHEMBL2320589 | 0.82 | CYP11B2 (0.45) | HTR6CHRNA1CHRNGCHRNB1CHRNB2 | |
| SCHEMBL1366189 | 0.82 | CYP11B2 (0.48) | HTR2CHTR6CHRNA1CHRNGCHRNB1 | |
| SCHEMBL21527353 | 0.80 | CHRNA1 (0.49) | HTR2CHTR6CHRNA1CHRNGCHRNB1 | |
| SCHEMBL19022096 | 0.80 | HTR6 (0.48) | HTR2CHTR6CHRNA1CHRNGCHRNB1 | |
| SCHEMBL5534626 | 0.79 | HTR2C (0.61) | HTR2CHTR6CHRNB2CHRNA4SLC6A2 | |
| SCHEMBL11894025 | 0.78 | CYP11B2 (0.44) | CHRNA1CHRNGCHRNB1CHRNB2CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102206206-A | Azabicyclooctane hydroximic acid derivatives, preparation method thereof, and application thereof in medicament | JIANGSU HENGRUI MEDICINE CO | 2011-10-05 | — | — | CN | disclosed |
| US-20110224189-A1 | SUBSTITUTED CYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES | INCYTE CORPORATION | 2011-09-15 | — | — | US | disclosed |
| US-7973041-B2 | Antiarthritic agents; psoriasis; anticancer agents;antiallergens; metalloprotease inhibitors. | INCYTE CORPORATION (US) | 2011-07-05 | — | — | US | disclosed |
| WO-2005117882-A2 | HYDROXAMIC ACID DERIVATIVES AS METALLOPROTEASE INHIBITORS | INCYTE CORPORATION (US) | 2005-12-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110224189-A1 | SUBSTITUTED CYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES | MMP25, MMP14, MMP9 | HTR2C 2401/4885HTR6 1891/4885CHRNA1 4590/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.