Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.35 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.32 |
| ▸ | LTA4H | P09960 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | APEX1 | P27695 | 1/20 | 0.30 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21756918 | 0.77 | GABRA1 (0.38) | SLC6A2SLC6A4GABRA1GABRB1GABRB2 | |
| SCHEMBL21756915 | 0.77 | GABRA1 (0.42) | SLC6A2SLC6A4HSP90AB1GABRA1GABRB1 | |
| SCHEMBL21756923 | 0.76 | SLC6A4 (0.46) | SLC6A2SLC6A4SLC6A3GABRA1GABRB1 | |
| SCHEMBL21756917 | 0.74 | GABRA1 (0.35) | GABRA1GABRB1GABRB2APEX1 | |
| SCHEMBL21756928 | 0.73 | SLC6A4 (0.39) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL21201601 | 0.72 | SLC6A4 (0.48) | SLC6A2SLC6A4SLC6A3HSP90AB1GABRA1 | |
| SCHEMBL12197671 | 0.71 | GABRA1 (0.52) | SLC6A2GABRA1GABRB1GABRB2CYP1A2 | |
| SCHEMBL21756933 | 0.70 | GABRA1 (0.41) | SLC6A2SLC6A4SLC6A3HSP90AB1GABRA1 | |
| SCHEMBL31378001 | 0.69 | SLC6A4 (0.36) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL16860570 | 0.69 | GABRA1 (0.44) | SLC6A2SLC6A3GABRA1GABRB1GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020039088-A2 | NOVEL COMPOUNDS | Xeniopro GmbH (DE) | 2020-02-27 | — | — | WO | disclosed |
| WO-2020039092-A2 | NOVEL AROMATIC MOLECULES | Xeniopro GmbH (DE) | 2020-02-27 | — | — | WO | disclosed |
| WO-2020039094-A1 | PHENOXY(HETERO)ARYL ETHERS OF ANTIPROLIFERATIVE ACTIVITY | Xeniopro GmbH (DE) | 2020-02-27 | — | — | WO | disclosed |
| US-9403829-B2 | Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino [2,3-b]pyrazin-2(1H)-one, a solid form thereof and methods of their use | SIGNAL PHARMACEUTICALS, LLC (US) | 2016-08-02 | — | — | US | disclosed |