Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.30 |
| ▸ | PNMT | P11086 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21756915 | 0.80 | GABRA1 (0.42) | GABRA1GABRB1GABRB2SLC6A2TRPA1 | |
| SCHEMBL21756923 | 0.78 | SLC6A4 (0.46) | GABRA1GABRB1GABRB2SLC6A2SLC6A4 | |
| SCHEMBL3849204 | 0.78 | SLC6A2 (0.50) | SLC6A2TRPA1LMNACHRM1ADRA1A | |
| SCHEMBL26137536 | 0.78 | HTR1D (0.40) | GABRA1GABRB2SLC6A2TRPA1LMNA | |
| SCHEMBL21756917 | 0.77 | GABRA1 (0.35) | GABRA1GABRB1GABRB2IDO1 | |
| SCHEMBL21756948 | 0.77 | SLC6A2 (0.38) | GABRA1GABRB1GABRB2SLC6A2SLC6A4 | |
| SCHEMBL18926879 | 0.76 | MPO (0.41) | SLC6A2SLC6A4IDO1 | |
| SCHEMBL3844310 | 0.76 | HTR2B (0.39) | GABRA1GABRB1GABRB2SLC6A2TRPA1 | |
| SCHEMBL3841008 | 0.76 | LMNA (0.47) | GABRA1GABRB1SLC6A2LMNAIDO1 | |
| SCHEMBL6861218 | 0.73 | CA1 (0.33) | GABRA1GABRB1GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020039088-A2 | NOVEL COMPOUNDS | Xeniopro GmbH (DE) | 2020-02-27 | — | — | WO | disclosed |
| WO-2020039094-A1 | PHENOXY(HETERO)ARYL ETHERS OF ANTIPROLIFERATIVE ACTIVITY | Xeniopro GmbH (DE) | 2020-02-27 | — | — | WO | disclosed |
| WO-2020039092-A2 | NOVEL AROMATIC MOLECULES | Xeniopro GmbH (DE) | 2020-02-27 | — | — | WO | disclosed |
| US-9403829-B2 | Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino [2,3-b]pyrazin-2(1H)-one, a solid form thereof and methods of their use | SIGNAL PHARMACEUTICALS, LLC (US) | 2016-08-02 | — | — | US | disclosed |