Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19676827 | 0.82 | CES2 (0.44) | ALDH1A1KMT2ASMN1; SMN2LMNAMEN1 | |
| SCHEMBL21758757 | 0.81 | GSK3B (0.43) | ALDH1A1KMT2AMEN1MAPTCYP2A6 | |
| SCHEMBL21758846 | 0.81 | CYP19A1 (0.41) | ALDH1A1LMNANPC1MAPTL3MBTL1 | |
| SCHEMBL21758759 | 0.80 | ALDH1A1 (0.37) | ALDH1A1MAPTGAA | |
| SCHEMBL21758828 | 0.80 | MAOA (0.44) | ALDH1A1KMT2ALMNAMAPT | |
| SCHEMBL21758845 | 0.78 | CTSL (0.35) | GSK3B | |
| SCHEMBL8730860 | 0.77 | TDP1 (0.46) | ALDH1A1KMT2ASMN1; SMN2LMNAMEN1 | |
| SCHEMBL21758833 | 0.77 | ALDH1A1 (0.38) | ALDH1A1KMT2ASMN1; SMN2MEN1CYP2A6 | |
| SCHEMBL11728908 | 0.77 | KMT2A (0.58) | ALDH1A1KMT2ASMN1; SMN2LMNAMEN1 | |
| SCHEMBL7197697 | 0.75 | ALDH1A1 (0.41) | ALDH1A1KMT2ASMN1; SMN2LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021221760-A2 | EXPANDING THE CHEMICAL SUBSTRATES FOR GENETIC CODE REPROGRAMMING TO INCLUDE LONG CHAIN CARBON AND CYCLIC AMINO ACIDS | NORTHWESTERN UNIVERSITY (US) | 2021-11-04 | — | — | WO | disclosed |
| WO-2020040840-A2 | EXPANDING THE CHEMICAL SUBSTRATES FOR GENETIC CODE REPROGRAMMING | NORTHWESTERN UNIVERSITY (US) | 2020-02-27 | — | — | WO | disclosed |