Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 3/20 | 0.41 |
| ▸ | MASP2 | O00187 | 1/20 | 0.34 |
| ▸ | PLAU | P00749 | 1/20 | 0.34 |
| ▸ | THPO | P40225 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 5/20 | 0.32 |
| ▸ | MAOB | P27338 | 4/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21758757 | 0.81 | GSK3B (0.43) | CYP19A1ALDH1A1MAPT | |
| SCHEMBL21758849 | 0.81 | ALDH1A1 (0.37) | LMNANPC1ALDH1A1L3MBTL1MAPT | |
| SCHEMBL21758843 | 0.80 | MEN1 (0.30) | — | |
| SCHEMBL21758828 | 0.80 | MAOA (0.44) | CYP19A1MAOAMAOBLMNAALDH1A1 | |
| SCHEMBL21758845 | 0.78 | CTSL (0.35) | MAOAMAOB | |
| SCHEMBL21758833 | 0.77 | ALDH1A1 (0.38) | CYP1A2CYP3A4ALDH1A1KDM4EHIF1A | |
| SCHEMBL21758759 | 0.77 | ALDH1A1 (0.37) | MAOAMAOBALDH1A1MAPT | |
| SCHEMBL14330440 | 0.74 | CYP19A1 (0.45) | CYP19A1MASP2PLAUTHPOF2 | |
| SCHEMBL21758755 | 0.73 | GFER (0.43) | CYP19A1MAOAMAOBCYP3A4ALDH1A1 | |
| SCHEMBL11696345 | 0.71 | LMNA (0.47) | CYP19A1MASP2PLAUTHPOMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021221760-A2 | EXPANDING THE CHEMICAL SUBSTRATES FOR GENETIC CODE REPROGRAMMING TO INCLUDE LONG CHAIN CARBON AND CYCLIC AMINO ACIDS | NORTHWESTERN UNIVERSITY (US) | 2021-11-04 | — | — | WO | disclosed |
| WO-2020040840-A2 | EXPANDING THE CHEMICAL SUBSTRATES FOR GENETIC CODE REPROGRAMMING | NORTHWESTERN UNIVERSITY (US) | 2020-02-27 | — | — | WO | disclosed |