SCHEMBL21759520

SCHEMBL21759520

CC(C)(C)[Si](C)(C)OCCCNc1ccccc1N

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DUT P33316 2/20 0.37
HDAC6 Q9UBN7 2/20 0.37
TLR8 Q9NR97 1/20 0.35
HDAC3 O15379 5/20 0.35
HDAC1 Q13547 5/20 0.35
HDAC2 Q92769 3/20 0.35
NCOR2 Q9Y618 2/20 0.35
PTGER4 P35408 1/20 0.34
CHRM2 P08172 1/20 0.34
NCF1 P14598 1/20 0.33
HDAC4 P56524 1/20 0.33
HDAC7 Q8WUI4 1/20 0.33
HDAC10 Q969S8 1/20 0.33
HDAC11 Q96DB2 1/20 0.33
HDAC8 Q9BY41 1/20 0.33
HDAC9 Q9UKV0 1/20 0.33
HDAC5 Q9UQL6 1/20 0.33
MAPT P10636 3/20 0.33
HTT P42858 2/20 0.33
GAA P10253 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30502135 0.93 NCF1 (0.36) DUTHDAC6HDAC3HDAC1PTGER4
SCHEMBL5545762 0.93 NCF1 (0.36) DUTHDAC6HDAC3HDAC1PTGER4
SCHEMBL12492803 0.82 L3MBTL1 (0.39) DUTHDAC6HDAC1CHRM2HDAC8
SCHEMBL12099097 0.81 AAK1 (0.35) DUTHDAC1PTGER4KDM4EALDH1A1
SCHEMBL12488340 0.80 MAPT (0.50) DUTMAPTALDH1A1RAB9ACYP1A2
SCHEMBL8615057 0.80 KCNH3 (0.44) DUTMAPTGAATDP1KDM4E
SCHEMBL24335879 0.78 PTGER4 (0.36) DUTHDAC6PTGER4
SCHEMBL7745287 0.78 PTGER4 (0.51) HDAC6HDAC3HDAC1HDAC2NCOR2
SCHEMBL1023801 0.78 DUT (0.38) DUTMAPTGAA
SCHEMBL35210229 0.78 HDAC3 (0.38) HDAC6TLR8HDAC3HDAC1HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4736882-A2 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE Cullgen (Shanghai), Inc. (CN) 2026-05-06 EP disclosed
EP-3841098-B1 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE CULLGEN SHANGHAI INC (CN) 2026-01-14 EP disclosed
US-20250388587-A1 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE CULLGEN SHANGHAI INC (CN) 2025-12-25 US disclosed
US-12410171-B2 Tropomyosin receptor kinase (TRK) degradation compounds and methods of use CULLGEN (SHANGHAI), INC. (CN) 2025-09-09 US disclosed
US-20240400570-A1 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE CULLGEN (SHANGHAI), INC. (CN) 2024-12-05 US disclosed
US-12065442-B2 Tropomyosin receptor kinase (TRK) degradation compounds and methods of use CULLGEN (SHANGHAI), INC. (CN) 2024-08-20 US disclosed
US-11969472-B2 Tropomyosin receptor kinase (TRK) degradation compounds and methods of use CULLGEN (SHANGHAI), INC. (CN) 2024-04-30 US disclosed
US-20230257380-A1 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE CULLGEN (SHANGHAI), INC. (CN) 2023-08-17 US disclosed
US-20230257380-A1 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE CULLGEN (SHANGHAI), INC. (CN) 2023-08-17 US disclosed
US-20210363146-A1 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE CULLGEN (SHANGHAI), INC. (CN) 2021-11-25 US disclosed
US-20210315999-A1 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE CULLGEN (SHANGHAI), INC. (CN) 2021-10-14 US disclosed
WO-2020038415-A1 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE CULLGEN (SHANGHAI), INC. (CN) 2020-02-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230257380-A1 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE MUSK, ERBB2, NTRK1 DUT 1292/4885HDAC6 606/4885TLR8 4008/4885
US-11969472-B2 Tropomyosin receptor kinase (TRK) degradation compounds and methods of use MUSK, ERBB2, NTRK1 DUT 1292/4885HDAC6 606/4885TLR8 4008/4885
US-12410171-B2 Tropomyosin receptor kinase (TRK) degradation compounds and methods of use MUSK, ERBB2, NTRK1 DUT 1292/4885HDAC6 606/4885TLR8 4008/4885
US-20250388587-A1 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE ERBB2, MUSK, ERBB3 DUT 3178/4885HDAC6 481/4885TLR8 3217/4885
US-20240400570-A1 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE MUSK, ERBB2, NTRK1 DUT 1292/4885HDAC6 606/4885TLR8 4008/4885
US-12065442-B2 Tropomyosin receptor kinase (TRK) degradation compounds and methods of use MUSK, NTRK1, ERBB2 DUT 1040/4885HDAC6 434/4885TLR8 4151/4885
US-20210363146-A1 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE MUSK, NTRK1, ERBB2 DUT 1040/4885HDAC6 434/4885TLR8 4151/4885
US-20210315999-A1 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE MUSK, ERBB2, NTRK1 DUT 1292/4885HDAC6 606/4885TLR8 4008/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.