Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Isosorbide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.40 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.40 |
| ▸ | GSR | P00390 | 3/20 | 0.33 |
| ▸ | BCHE | P06276 | 3/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isosorbide SCHEMBL3388024 | 1.00 | THRB (0.65) | THRBLMNAMAPTALDH1A1CA5A | |
| Isosorbide SCHEMBL217707 | 1.00 | THRB (0.65) | THRBLMNAMAPTALDH1A1CA5A | |
| Isosorbide SCHEMBL2129898 | 1.00 | THRB (0.65) | THRBLMNAMAPTALDH1A1CA5A | |
| Isosorbide SCHEMBL5699287 | 1.00 | THRB (0.65) | THRBLMNAMAPTALDH1A1CA5A | |
| Isosorbide SCHEMBL5170125 | 1.00 | THRB (0.65) | THRBLMNAMAPTALDH1A1CA5A | |
| Isosorbide SCHEMBL27944142 | 0.90 | THRB (0.65) | THRBLMNAMAPTALDH1A1GSR | |
| Isosorbide SCHEMBL8414428 | 0.84 | THRB (0.56) | THRBLMNAMAPTALDH1A1GSR | |
| Isosorbide Mononitrate SCHEMBL919022 | 0.83 | MAPT (0.93) | THRBLMNAMAPTALDH1A1GSR | |
| Isosorbide SCHEMBL24465084 | 0.81 | THRB (1.00) | THRBLMNAMAPTBCHE | |
| Isosorbide SCHEMBL6298736 | 0.81 | THRB (1.00) | THRBLMNAMAPTBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040063684-A1 | Treatment of oesophageal motility disorders and gastro-oesophageal reflux disease | KAMM MICHAEL A (GB) | 2004-04-01 | — | — | US | claimed |
| EP-1357905-A2 | A TREATMENT OF OESOPHAGEAL MOTILITY DISORDERS AND GASTRO-OESOPHAGEAL REFLUX DISEASE | Kamm, Michael Albert (GB) | 2003-11-05 | — | — | EP | claimed |
| WO-2002062324-A2 | A TREATMENT OF OESOPHAGEAL MOTILITY DISORDERS AND GASTRO-OESOPHAGEAL REFLUX DISEASE | KAMM MICHAEL ALBERT (GB) | 2002-08-15 | — | — | WO | claimed |
| US-11166931-B2 | Induction of arteriogenesis with an NO (nitric oxide) donor | G. POHL-BOSKAMP GMBH & CO. KG (DE) | 2021-11-09 | — | — | US | disclosed |
| EP-2877170-B1 | INDUCTION OF ARTERIOGENESIS WITH NITROGLYCERINE | G POHL BOSKAMP GMBH & CO KG (DE) | 2019-04-10 | — | — | EP | disclosed |
| EP-3412285-A2 | INDUCTION OF ARTERIOGENESIS | G. Pohl-Boskamp GmbH & Co. KG (DE) | 2018-12-12 | — | — | EP | disclosed |
| US-20170172966-A1 | INDUCTION OF ARTERIOGENESIS WITH AN NO (NITRIC OXIDE) DONOR | G. POHL-BOSKAMP GMBH & CO. KG (DE) | 2017-06-22 | — | — | US | disclosed |
| US-20150164845-A1 | INDUCTION OF ARTERIOGENESIS WITH AN NO (NITRIC OXIDE) DONOR | POHL BOSKAMP G GMBH & CO KG (DE) | 2015-06-18 | — | — | US | disclosed |
| EP-2877170-A1 | INDUCTION OF ARTERIOGENESIS WITH AN NO (NITRIC OXIDE) DONOR | G. Pohl-Boskamp GmbH & Co. KG (DE) | 2015-06-03 | — | — | EP | disclosed |
| US-20150025060-A1 | Foamable Compositions and Kits Comprising One or More of a Channel Agent, a Cholinergic Agent, A nitric Oxide Donor and Related Agents and Their Uses | FOAMIX LTD. (IL) | 2015-01-22 | — | — | US | disclosed |
| WO-2013178715-A1 | INDUCTION OF ARTERIOGENESIS WITH AN NO (NITRIC OXIDE) DONOR | G. POHL-BOSKAMP GMBH & CO. KG (DE) | 2013-12-05 | — | — | WO | disclosed |
| WO-2008110872-A2 | FOAMABLE COMPOSITIONS AND KITS COMPRISING ONE OR MORE OF A CHANNEL AGENT, A CHOLINERGIC AGENT, A NITRIC OXIDE DONOR, AND RELATED AGENTS AND THEIR USES | FOAMIX LTD. (US) | 2008-09-18 | — | — | WO | disclosed |
| US-20050070607-A1 | N-acetylcysteine compositions and methods for the treatment and prevention of cysteine/glutathione deficiency in diseases and conditions | ANDRUS JAMES (US) | 2005-03-31 | — | — | US | disclosed |
| EP-1351698-A4 | HERBAL COMPOSITION FOR ANGINA PECTORIS, METHOD TO PREPARE SAME AND USES THEREOF | TIANJIN TASLY PHARMACEUTICAL (CN) | 2004-11-03 | — | — | EP | disclosed |
| US-20040063684-A1 | Treatment of oesophageal motility disorders and gastro-oesophageal reflux disease | KAMM MICHAEL A (GB) | 2004-04-01 | — | — | US | disclosed |
| EP-1357905-A2 | A TREATMENT OF OESOPHAGEAL MOTILITY DISORDERS AND GASTRO-OESOPHAGEAL REFLUX DISEASE | Kamm, Michael Albert (GB) | 2003-11-05 | — | — | EP | disclosed |
| EP-1351698-A2 | HERBAL COMPOSITION FOR ANGINA PECTORIS, METHOD TO PREPARE SAME AND USES THEREOF | Tianjin Tasly Pharmaceutical Co., Ltd., China (CN) | 2003-10-15 | — | — | EP | disclosed |
| US-20030152651-A1 | Herbal composition for angina pectoris, method to prepare same and uses thereof | TIANJIN TASLY PHARMACEUTICAL CO., LTD., CHINA | 2003-08-14 | — | — | US | disclosed |
| WO-2002062324-A2 | A TREATMENT OF OESOPHAGEAL MOTILITY DISORDERS AND GASTRO-OESOPHAGEAL REFLUX DISEASE | KAMM MICHAEL ALBERT (GB) | 2002-08-15 | — | — | WO | disclosed |
| WO-2002058625-A2 | HERBAL COMPOSITION FOR ANGINA PECTORIS, METHOD TO PREPARE SAME AND USES THEREOF | TIANJIN TASLY PHARMACEUTICAL CO., LTD., CHINA (CN) | 2002-08-01 | — | — | WO | disclosed |