Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 11/20 | 0.45 |
| ▸ | MAOA | P21397 | 9/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 5/20 | 0.44 |
| ▸ | CA1 | P00915 | 4/20 | 0.44 |
| ▸ | CA2 | P00918 | 3/20 | 0.44 |
| ▸ | CA7 | P43166 | 3/20 | 0.44 |
| ▸ | CA5B | Q9Y2D0 | 3/20 | 0.44 |
| ▸ | CA4 | P22748 | 3/20 | 0.44 |
| ▸ | CA5A | P35218 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 3/20 | 0.44 |
| ▸ | CA6 | P23280 | 2/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.44 |
| ▸ | CA3 | P07451 | 1/20 | 0.44 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18551620 | 0.88 | LMNA (0.49) | HPGDTSHRSMN1; SMN2MAOBMAOA | |
| SCHEMBL20233723 | 0.85 | ADRB2 (0.48) | HPGDTSHRSMN1; SMN2MAOBMAOA | |
| SCHEMBL21950993 | 0.82 | CA9 (0.59) | HPGDSMN1; SMN2MAOBCYP2D6CA12 | |
| SCHEMBL18551617 | 0.79 | HPGD (0.46) | HPGDTSHRSMN1; SMN2MAOBCA4 | |
| SCHEMBL15623151 | 0.79 | LMNA (0.51) | HPGDTSHRSMN1; SMN2MAOBCA4 | |
| SCHEMBL18611776 | 0.78 | KDM4E (0.50) | HPGDTSHRSMN1; SMN2MAOBMAOA | |
| SCHEMBL1391034 | 0.77 | SLC16A3 (0.65) | MAOBMAOACA12CA1CA2 | |
| SCHEMBL1287537 | 0.77 | ALDH1A1 (0.66) | HPGDTSHRSMN1; SMN2MAOBCYP2D6 | |
| SCHEMBL20334181 | 0.76 | TAS1R3 (0.48) | HPGDTSHRSMN1; SMN2CA4LMNA | |
| SCHEMBL3825039 | 0.76 | CA2 (0.65) | HPGDSMN1; SMN2MAOBCYP2D6CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3689868-A1 | TETRAHYDRONAPHTHALENE AND TETRAHYDROISOQUINOLINE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS | Arvinas Operations, Inc. (US) | 2020-08-05 | — | — | EP | disclosed |
| WO-2020041331-A1 | PROTEOLYSIS TARGETING CHIMERIC (PROTAC) COMPOUND WITH E3 UBIQUITIN LIGASE BINDING ACTIVITY AND TARGETING ALPHA-SYNUCLEIN PROTEIN FOR TREATING NEURODEGENERATIVE DISEASES | ARVINAS OPERATIONS, INC. (US) | 2020-02-27 | — | — | WO | disclosed |