Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.64 |
| ▸ | NPC1 | O15118 | 3/20 | 0.64 |
| ▸ | RAB9A | P51151 | 3/20 | 0.64 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.54 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.54 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | IKBKB | O14920 | 2/20 | 0.47 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.46 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TYR | P14679 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3293191 | 0.86 | NPC1 (0.75) | KDM4ENPC1RAB9AS1PR1NR1H4 | |
| SCHEMBL2623780 | 0.86 | NPC1 (0.75) | KDM4ENPC1RAB9AS1PR1NR1H4 | |
| SCHEMBL969124 | 0.85 | KDM4E (0.64) | KDM4ENPC1RAB9AS1PR1NR1H4 | |
| SCHEMBL4017705 | 0.85 | KDM4E (0.64) | KDM4ENPC1RAB9AS1PR1NR1H4 | |
| SCHEMBL6296907 | 0.84 | NPC1 (0.72) | KDM4ENPC1RAB9AS1PR1NR1H4 | |
| SCHEMBL1104799 | 0.84 | NPC1 (0.72) | KDM4ENPC1RAB9AS1PR1NR1H4 | |
| SCHEMBL18741407 | 0.84 | KDM4E (0.62) | KDM4ENPC1RAB9AS1PR1NR1H4 | |
| SCHEMBL21777008 | 0.81 | KDM4E (0.62) | KDM4ENPC1RAB9ANOTUMIKBKB | |
| SCHEMBL12427246 | 0.81 | NPC1 (0.68) | KDM4ENPC1RAB9AS1PR1NR1H4 | |
| SCHEMBL460873 | 0.81 | NPC1 (0.68) | KDM4ENPC1RAB9AS1PR1NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11634391-B2 | Compounds which are inhibitors of Notum | UCL BUSINESS LTD (GB) | 2023-04-25 | — | — | US | disclosed |
| US-20210171475-A1 | COMPOUNDS | UCL BUSINESS LTD (GB) | 2021-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11634391-B2 | Compounds which are inhibitors of Notum | NOTUM, GOT2, GOT1 | KDM4E 3907/4885NPC1 51/4885RAB9A 2177/4885 |
| US-20210171475-A1 | COMPOUNDS | GOT2, GOT1, OAT | KDM4E 4149/4885NPC1 7/4885RAB9A 1162/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.