Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 17/20 | 0.50 |
| ▸ | ALOX5AP | P20292 | 15/20 | 0.50 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.45 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | RXRB | P28702 | 1/20 | 0.43 |
| ▸ | RXRG | P48443 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18784923 | 0.83 | ALOX5AP (0.44) | FEN1ALOX5APMRGPRX4RXRARXRB | |
| SCHEMBL21778753 | 0.81 | MRGPRX4 (0.42) | FEN1ALOX5APMRGPRX4RXRARXRB | |
| SCHEMBL14729682 | 0.77 | RXRA (0.47) | FEN1ALOX5APMRGPRX4RXRARXRB | |
| SCHEMBL8429140 | 0.74 | MRGPRX4 (0.67) | MRGPRX4RXRA | |
| SCHEMBL25261119 | 0.71 | FEN1 (0.58) | FEN1ALOX5AP | |
| SCHEMBL4284174 | 0.71 | MRGPRX4 (0.52) | MRGPRX4RXRARXRBRXRG | |
| SCHEMBL1333232 | 0.70 | HTR2C (0.58) | MRGPRX4RXRARXRBRXRG | |
| SCHEMBL8619233 | 0.70 | MAOB (0.44) | FEN1ALOX5AP | |
| SCHEMBL8614719 | 0.70 | FEN1 (0.49) | FEN1ALOX5AP | |
| SCHEMBL30956744 | 0.69 | GABRG2 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210230137-A1 | PYRAZINE COMPOUND | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2021-07-29 | — | — | US | disclosed |
| US-11001567-B2 | Pyrazine compound | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2021-05-11 | — | — | US | disclosed |
| US-20200109128-A1 | PYRAZINE COMPOUND | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2020-04-09 | — | — | US | disclosed |
| US-10577343-B2 | Pyrazine compound and arthropod pest control agent containing same | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2020-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210230137-A1 | PYRAZINE COMPOUND | PPOX, NOX5, NISCH | FEN1 4522/4885ALOX5AP 381/4885MRGPRX4 1428/4885 |
| US-10577343-B2 | Pyrazine compound and arthropod pest control agent containing same | PPOX, NOX5, NISCH | FEN1 4678/4885ALOX5AP 213/4885MRGPRX4 1440/4885 |
| US-11001567-B2 | Pyrazine compound | PPOX, NOX5, NISCH | FEN1 4522/4885ALOX5AP 381/4885MRGPRX4 1428/4885 |
| US-20200109128-A1 | PYRAZINE COMPOUND | PPOX, NOX5, NISCH | FEN1 4522/4885ALOX5AP 381/4885MRGPRX4 1428/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.