Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR142 | Q7Z601 | 8/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.32 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.32 |
| ▸ | ITGAL | P20701 | 2/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.31 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25955573 | 0.88 | ITGB2 (0.33) | GPR142CYP2D6CYP2C9KCNH2CYP3A4 | |
| SCHEMBL25338102 | 0.79 | GPR142 (0.37) | GPR142CYP2D6CYP2C9KCNH2CYP3A4 | |
| SCHEMBL25955625 | 0.74 | PDE10A (0.35) | GPR142CYP2D6CYP2C9KCNH2TRPV1 | |
| SCHEMBL21780467 | 0.74 | KCNH2 (0.45) | GPR142CYP2D6CYP2C9KCNH2CYP3A4 | |
| SCHEMBL25955647 | 0.72 | PDE10A (0.40) | — | |
| SCHEMBL22563248 | 0.69 | TLR8 (0.36) | GPR142CYP2D6CYP2C9KCNH2CYP3A4 | |
| SCHEMBL25374988 | 0.68 | ADORA2A (0.44) | KCNH2CREBBP | |
| SCHEMBL21780488 | 0.66 | ROCK2 (0.36) | GPR142CYP2D6CYP2C9KCNH2CYP3A4 | |
| SCHEMBL30544079 | 0.66 | GPR142 (0.36) | GPR142CYP2D6CYP2C9KCNH2CYP3A4 | |
| SCHEMBL25339990 | 0.66 | GPR142 (0.36) | GPR142CYP2D6CYP2C9KCNH2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023146511-A1 | COMPOUNDS AND METHODS OF USE THEREOF | VIVACE THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | disclosed |