Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 6/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.32 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP3 | P08254 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2180329 | 0.87 | CHRNB2 (0.34) | CHRNB2CHRNB4CHRNA3CHRNA4MT-CO2 | |
| SCHEMBL2179019 | 0.85 | MT-CO2 (0.35) | CHRNB2CHRNB4CHRNA3CHRNA4MT-CO2 | |
| SCHEMBL2176988 | 0.78 | AAK1 (0.33) | MT-CO2CTSSCTSKAAK1 | |
| SCHEMBL1164018 | 0.76 | L3MBTL1 (0.37) | MT-CO2CTSSCTSKGSK3B | |
| SCHEMBL3868314 | 0.73 | CHRNB2 (0.41) | CHRNB2CHRNB4CHRNA3CHRNA4MT-CO2 | |
| SCHEMBL6650593 | 0.72 | CHRNB2 (0.42) | CHRNB2CHRNB4CHRNA3CHRNA4ABCB1 | |
| SCHEMBL2178893 | 0.70 | ABCB1 (0.34) | CHRNB2CHRNB4CHRNA3CHRNA4ABCB1 | |
| SCHEMBL28847028 | 0.70 | ABCB1 (0.38) | CTSSCTSKCYP19A1ABCB1NCEH1 | |
| SCHEMBL38651897 | 0.70 | MLYCD (0.50) | CHRNB2CHRNB4CHRNA3CHRNA4GPR119 | |
| SCHEMBL12484843 | 0.70 | PDE4B (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130289000-A1 | BORON-CONTAINING SMALL MOLECULES | ANACOR PHARMACEUTICALS INC (US) | 2013-10-31 | — | — | US | disclosed |
| US-8470803-B2 | Boron-containing small molecules | ANACOR PHARMACEUTICALS, INC. (US) | 2013-06-25 | — | — | US | disclosed |
| US-20110166103-A1 | BORON-CONTAINING SMALL MOLECULES | ANACOR PHARMACEUTICALS, INC. (US) | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166103-A1 | BORON-CONTAINING SMALL MOLECULES | NFKBIA, BCL6B, TNF | CHRNB2 3527/4885CHRNB4 3916/4885CHRNA3 4634/4885 |
| US-20130289000-A1 | BORON-CONTAINING SMALL MOLECULES | NFKBIA, BCL6B, TNF | CHRNB2 3527/4885CHRNB4 3916/4885CHRNA3 4634/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.