Sugi Predict

Sugi Predict / Compounds / SCHEMBL2178580

SCHEMBL2178580

SCHEMBL2178580

CC(C)C(C(=O)O)N1Cc2ccc(-c3ccc(NS(=O)(=O)c4ccc(C(F)(F)F)cc4)cc3)cc2C1=O

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MMP13 P45452 2/20 0.47
▸ MMP2 P08253 2/20 0.47
▸ MMP9 P14780 2/20 0.47
▸ MMP1 P03956 1/20 0.47
▸ MMP3 P08254 1/20 0.47
▸ MMP7 P09237 1/20 0.47
▸ ACLY P53396 1/20 0.42
▸ KDM1A O60341 2/20 0.42
▸ ERAP1 Q9NZ08 1/20 0.41
▸ LMNA P02545 1/20 0.41
▸ HSPD1 P10809 1/20 0.40
▸ PTPN2 P17706 1/20 0.40
▸ PTPN1 P18031 1/20 0.40
▸ PTPN5 P54829 1/20 0.40
▸ HSPE1 P61604 1/20 0.40
▸ BRD4 O60885 1/20 0.40
▸ KIT P10721 1/20 0.40
▸ HDAC3 O15379 1/20 0.40
▸ HDAC4 P56524 1/20 0.40
▸ HDAC1 Q13547 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2182303 1.00 MMP13 (0.47) MMP13MMP2MMP9MMP1MMP3
SCHEMBL2179727 0.93 MMP13 (0.47) MMP13MMP2MMP9MMP1MMP3
SCHEMBL2177958 0.93 MMP13 (0.47) MMP13MMP2MMP9MMP1MMP3
SCHEMBL2181348 0.89 SDCBP (0.47) MMP2LMNABRD4SDCBPSDC2
SCHEMBL2179343 0.89 SDCBP (0.47) MMP2LMNABRD4SDCBPSDC2
SCHEMBL2296052 0.89 SDCBP (0.43) MMP13MMP2MMP9MMP1MMP3
SCHEMBL2179719 0.87 LMNA (0.41) ACLYLMNAKITMEN1KMT2A
SCHEMBL2180935 0.87 LMNA (0.51) MMP13MMP2MMP9MMP1MMP3
SCHEMBL2179136 0.87 LMNA (0.41) ACLYLMNAKITMEN1KMT2A
SCHEMBL2180749 0.87 LMNA (0.51) MMP13MMP2MMP9MMP1MMP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8748426-B2 Inhibitors of diacylglycerol acyl transferase Piramal Enterprises Limited (IN) 2014-06-10 — — US claimed
US-20120289505-A1 INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE Piramal Enterprises Limited (IN) 2012-11-15 — — US claimed
EP-2519500-A1 INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE Piramal Healthcare Ltd. (IN) 2012-11-07 — — EP claimed
WO-2011080718-A1 INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE PIRAMAL LIFE SCIENCES LIMITED (IN) 2011-07-07 — — WO claimed
US-8748426-B2 Inhibitors of diacylglycerol acyl transferase Piramal Enterprises Limited (IN) 2014-06-10 — — US disclosed
US-20120289505-A1 INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE Piramal Enterprises Limited (IN) 2012-11-15 — — US disclosed
EP-2519500-A1 INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE Piramal Healthcare Ltd. (IN) 2012-11-07 — — EP disclosed
WO-2011080718-A1 INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE PIRAMAL LIFE SCIENCES LIMITED (IN) 2011-07-07 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120289505-A1 INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE DGAT1, DGAT2, LCAT MMP13 2554/4885MMP2 2740/4885MMP9 3722/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.