Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SDCBP | O00560 | 5/20 | 0.43 |
| ▸ | SDC2 | P34741 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MMP7 | P09237 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2179995 | 0.93 | DGAT1 (0.45) | SDCBPSDC2LMNATP53THRB | |
| SCHEMBL2179990 | 0.93 | DGAT1 (0.45) | SDCBPSDC2LMNATP53THRB | |
| SCHEMBL2181505 | 0.91 | MEN1 (0.45) | LMNATP53 | |
| SCHEMBL2181500 | 0.91 | MEN1 (0.45) | LMNATP53 | |
| SCHEMBL2178580 | 0.89 | MMP13 (0.47) | SDCBPSDC2LMNAMMP1MMP2 | |
| SCHEMBL2182303 | 0.89 | MMP13 (0.47) | SDCBPSDC2LMNAMMP1MMP2 | |
| SCHEMBL2282134 | 0.87 | THRB (0.52) | SDCBPSDC2LMNATP53THRB | |
| SCHEMBL2289376 | 0.87 | SDCBP (0.44) | SDCBPSDC2LMNATP53THRB | |
| SCHEMBL2177517 | 0.86 | TRPV4 (0.47) | SDCBPSDC2LMNATP53THRB | |
| SCHEMBL2177522 | 0.86 | TRPV4 (0.47) | SDCBPSDC2LMNATP53THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519500-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | Piramal Healthcare Ltd. (IN) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011080718-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2011-07-07 | — | — | WO | disclosed |