Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 1/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.52 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | CPT2 | P23786 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.35 |
| ▸ | CTH | P32929 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18011682 | 0.79 | KDM4E (0.48) | HMGCRCHRM1TBXA2RADRA1ACYP2C19 | |
| Hydrochloric Acid SCHEMBL4137653 | 0.79 | TSHR (0.60) | HMGCRCHRM1TBXA2RADRA1ACYP2C19 | |
| SCHEMBL83915 | 0.79 | TSHR (0.60) | HMGCRCHRM1TBXA2RADRA1ACYP2C19 | |
| SCHEMBL9015652 | 0.79 | ALDH1A1 (0.37) | HMGCRCHRM1TBXA2RADRA1ACYP2C19 | |
| SCHEMBL4932094 | 0.78 | HMGCR (0.48) | HMGCRCHRM1TBXA2RADRA1ACYP2C19 | |
| SCHEMBL28478983 | 0.77 | TSHR (0.57) | HMGCRCHRM1TBXA2RADRA1ACYP2C19 | |
| Ammonia Solution, Strong SCHEMBL10868076 | 0.77 | TSHR (0.57) | HMGCRCHRM1TBXA2RADRA1ACYP2C19 | |
| Ammonia Solution, Strong SCHEMBL10870096 | 0.77 | TSHR (0.57) | HMGCRCHRM1TBXA2RADRA1ACYP2C19 | |
| SCHEMBL8844260 | 0.77 | TSHR (0.57) | HMGCRCHRM1TBXA2RADRA1ACYP2C19 | |
| SCHEMBL6739451 | 0.77 | TSHR (0.57) | HMGCRCHRM1TBXA2RADRA1ACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3253752-B1 | [9,10-DIMETHOXY-3-(2-METHYLPROPYL)-1H,2H,3H,4H,6H,7H,11BH-PYRIDO-[2,1-A]ISOQUINOLIN-2-YL]METHANOL AND COMPOUNDS, COMPOSITIONS AND METHODS RELATING THERETO | NEUROCRINE BIOSCIENCES INC (US) | 2023-08-16 | — | — | EP | disclosed |
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |
| US-9849112-B2 | Pyrrole compounds as Granzyme B inhibitors | VIDA THERAPEUTICS INC. (CA) | 2017-12-26 | — | — | US | disclosed |
| WO-2017132771-A1 | GRANZYME B INHIBITOR FORMULATIONS AND METHODS FOR THE TREATMENT OF BURNS | VIDA THERAPEUTICS, INC. (CA) | 2017-08-10 | — | — | WO | disclosed |
| US-20170218014-A1 | AZAINDOLINE COMPOUNDS AS GRANZYME B INHIBITORS | VIDA THERAPEUTICS INC. (CA) | 2017-08-03 | — | — | US | disclosed |
| US-20170015705-A1 | PYRROLE COMPOUNDS AS GRANZYME B INHIBITORS | VIDA THERAPEUTICS INC. (CA) | 2017-01-19 | — | — | US | disclosed |
| US-20170015707-A1 | COVALENT GRANZYME B INHIBITORS | VIDA THERAPEUTICS INC. (CA) | 2017-01-19 | — | — | US | disclosed |
| US-20170015706-A1 | PROLINE COMPOUNDS AS GRANZYME B INHIBITORS | VIDA THERAPEUTICS INC. (CA) | 2017-01-19 | — | — | US | disclosed |
| US-9458138-B1 | Pyrrole compounds as granzyme B inhibitors | viDATherapeutics Inc. (CA) | 2016-10-04 | — | — | US | disclosed |
| US-9458193-B1 | Proline compounds as Granzyme B inhibitors | VIDA THERAPEUTICS INC. (CA) | 2016-10-04 | — | — | US | disclosed |
| US-4056537-A | CYCLIZATION, ACID CATALYST | AYERST MCKENNA AND HARRISON LTD. (CA) | 1977-11-01 | — | — | US | disclosed |
| US-4056538-A | ANTIDEPRESSANTS, ANTIULCER AGENTS | AYERST, MCKENNA & HARRISON LIMITED (CA) | 1977-11-01 | — | — | US | disclosed |
| US-4041169-A | TREATING AND PREVENTING ULCERS | AYERST MCKENNA AND HARRISON LTD. (CA) | 1977-08-09 | — | — | US | disclosed |
| US-4035495-A | HYPERTENSIVE AGENTS, CNS DEPRESSANT | AYERST MCKENNA AND HARRISON LTD. (CA) | 1977-07-12 | — | — | US | disclosed |
| US-4012511-A | ANTIULCER AGENTS | AYERST MCKENNA & HARRISON LTD. (CA) | 1977-03-15 | — | — | US | disclosed |
| US-4012417-A | ACID CATALYSTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1977-03-15 | — | — | US | disclosed |
| US-4003913-A | ANTIDEPRESSANTS, ANTIULCER AGENTS | AYERST MCKENNA AND HARRISON LTD. (CA) | 1977-01-18 | — | — | US | disclosed |
| US-3995052-A | Indenopyran- and indenothiopyranalkylamines III in the treatment of depression | AYERST MCKENNA AND HARRISON LTD. (CA) | 1976-11-30 | — | — | US | disclosed |
| US-3974179-A | ANTIINFLAMMATORY, ANALGESICS, BACTERICIDES, FUNGICIDES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1976-08-10 | — | — | US | disclosed |
| US-3962236-A | ANTIDEPRESSANTS, ANTI-ULCER | AYERST MCKENNA AND HARRISON LTD. (CA) | 1976-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170218014-A1 | AZAINDOLINE COMPOUNDS AS GRANZYME B INHIBITORS | GZMB, DNASE1L3, DNASE1 | HMGCR 4120/4885CHRM1 4769/4885TBXA2R 2921/4885 |
| US-20170015705-A1 | PYRROLE COMPOUNDS AS GRANZYME B INHIBITORS | GZMB, CTSB, DNASE1L3 | HMGCR 3220/4885CHRM1 4871/4885TBXA2R 3920/4885 |
| US-20170015707-A1 | COVALENT GRANZYME B INHIBITORS | GZMB, CTSB, DNASE1L3 | HMGCR 3416/4885CHRM1 4830/4885TBXA2R 3017/4885 |
| US-20170015706-A1 | PROLINE COMPOUNDS AS GRANZYME B INHIBITORS | GZMB, CTSB, RNPEP | HMGCR 3404/4885CHRM1 4880/4885TBXA2R 4017/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.