Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | CES1 | P23141 | 2/20 | 0.50 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MEP1B | Q16820 | 2/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6204912 | 0.85 | L3MBTL1 (0.50) | LMNACES1CES2TDP1L3MBTL1 | |
| SCHEMBL11368221 | 0.84 | CYP2D6 (0.47) | LMNAATMCYP2D6MEN1MAPK1 | |
| SCHEMBL6203337 | 0.79 | TDP1 (0.50) | LMNACES1CES2TDP1L3MBTL1 | |
| SCHEMBL6201593 | 0.78 | ALDH1A1 (0.54) | LMNACES1CES2TDP1L3MBTL1 | |
| SCHEMBL6202101 | 0.78 | MEP1B (0.57) | LMNACES1CES2TDP1L3MBTL1 | |
| SCHEMBL6202507 | 0.77 | SMN1; SMN2 (0.48) | LMNACES1CES2TDP1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL10525622 | 0.77 | ALDH1A1 (0.52) | LMNACES1CES2TDP1L3MBTL1 | |
| SCHEMBL6321040 | 0.75 | HAT1 (0.54) | — | |
| SCHEMBL3127115 | 0.74 | CTSS (0.46) | L3MBTL1SMN1; SMN2ATMMEN1MAPT | |
| SCHEMBL23861285 | 0.73 | TDP1 (0.55) | LMNACES1CES2TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5876956-A | INTACT, VIABLE HUMAN PLURIPOTENT HEMATOPOEITIC STEM CELLS ISOLATED BY EXPRESSION OF INTRACELLULAR MARKER, CYTOSOLIC ALDEHYDE DEHYDROGENASE; FOR BONE MARROW TRANSPLANTS | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 1999-03-02 | — | — | US | disclosed |
| WO-1996036344-A1 | INTRACELLULAR MARKER FOR PURIFICATION OF STEM CELLS | THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 1996-11-21 | — | — | WO | disclosed |