Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | TP53 | P04637 | 4/20 | 0.40 |
| ▸ | HBB | P68871 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11542621 | 0.79 | DRD2 (0.43) | ALOX12ALDH1A1TDP1GLAPOLB | |
| SCHEMBL9651195 | 0.79 | DRD2 (0.43) | ALOX12ALDH1A1TDP1GLAPOLB | |
| SCHEMBL22446070 | 0.78 | TP53 (0.39) | SMN1; SMN2TP53HBBTSHRALDH1A1 | |
| SCHEMBL5435139 | 0.74 | TP53 (0.48) | SMN1; SMN2TP53HBBTSHRALDH1A1 | |
| SCHEMBL7002095 | 0.72 | GAA (0.51) | SMN1; SMN2TP53TSHRALDH1A1TDP1 | |
| SCHEMBL13479863 | 0.69 | GRM2 (0.35) | SMN1; SMN2ALOX12LMNA | |
| SCHEMBL16290005 | 0.69 | ALOX12 (0.53) | SMN1; SMN2ALOX12ALDH1A1LMNAGAA | |
| SCHEMBL964091 | 0.67 | SMN1; SMN2 (0.56) | SMN1; SMN2TP53HBBTSHRALDH1A1 | |
| SCHEMBL23116291 | 0.67 | TP53 (0.36) | SMN1; SMN2TP53HBBTSHRALDH1A1 | |
| SCHEMBL28493276 | 0.66 | TP53 (0.35) | SMN1; SMN2TP53HBBTSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402037-B1 | CONTROLLED RELEASE OF PHENOLIC OPIOIDS | SIGNATURE THERAPEUTICS INC (US) | 2019-10-23 | — | — | EP | disclosed |
| US-20150148284-A1 | Controlled Release of Phenolic Opioids | PHARMACOFORE, INC. | 2015-05-28 | — | — | US | disclosed |
| US-8921418-B2 | Controlled release of phenolic opioids | SIGNATURE THERAPEUTICS, INC. (US) | 2014-12-30 | — | — | US | disclosed |
| EP-2046393-B1 | CONTROLLED RELEASE OF PHENOLIC OPIOIDS | SIGNATURE THERAPEUTICS INC (US) | 2014-02-12 | — | — | EP | disclosed |
| US-20120270894-A1 | Controlled Release of Phenolic Opioids | 3I, LP | 2012-10-25 | — | — | US | disclosed |
| US-8217005-B2 | Controlled release of phenolic opioids | SIGNATURE THERAPEUTICS, INC. (US) | 2012-07-10 | — | — | US | disclosed |
| US-20120142718-A1 | N-17-Alkylated Prodrugs of Opioids | SIGNATURE THERAPEUTICS, INC. | 2012-06-07 | — | — | US | disclosed |
| EP-2402037-A1 | Controlled release of phenolic opioids | Pharmacofore, Inc. (US) | 2012-01-04 | — | — | EP | disclosed |
| US-20110105381-A2 | Prodrugs of Peripheral Phenolic Opioid Antagonists | PHARMACOFORE, INC. (US) | 2011-05-05 | — | — | US | disclosed |
| US-20100267614-A1 | Prodrugs of Peripheral Phenolic Opioid Antagonists | PHARMACOFORE, INC. | 2010-10-21 | — | — | US | disclosed |
| US-20100035826-A1 | CONTROLLED RELEASE OF PHENOLIC OPIOIDS | Phamacofoce, Inc. (CA) | 2010-02-11 | — | — | US | disclosed |
| EP-2046393-A2 | CONTROLLED RELEASE OF PHENOLIC OPIOIDS | Pharmacofore, Inc. (US) | 2009-04-15 | — | — | EP | disclosed |
| WO-2008101202-A1 | N-17-ALKYLATED PRODRUGS OF OPIOIDS | PHARMACOFORE, INC. (US) | 2008-08-21 | — | — | WO | disclosed |
| WO-2008101187-A2 | PRO-DRUGS OF PERIPHERAL PHENOLIC OPIOID ANTAGONISTS | PHARMACOFORE, INC. (US) | 2008-08-21 | — | — | WO | disclosed |
| WO-2007140272-A2 | CONTROLLED RELEASE OF PHENOLIC OPIOIDS | PHARMACOFORE, INC. (US) | 2007-12-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120270894-A1 | Controlled Release of Phenolic Opioids | OPRK1, OPRM1, OPRD1 | SMN1; SMN2 3704/4885TP53 4322/4885HBB 944/4885 |
| US-20150148284-A1 | Controlled Release of Phenolic Opioids | OPRK1, OPRM1, OPRD1 | SMN1; SMN2 3704/4885TP53 4322/4885HBB 944/4885 |
| US-20110105381-A2 | Prodrugs of Peripheral Phenolic Opioid Antagonists | OPRM1, OPRL1, OPRK1 | SMN1; SMN2 2464/4885TP53 4814/4885HBB 1638/4885 |
| US-20100035826-A1 | CONTROLLED RELEASE OF PHENOLIC OPIOIDS | OPRK1, OPRM1, OPRD1 | SMN1; SMN2 3704/4885TP53 4322/4885HBB 944/4885 |
| US-20120142718-A1 | N-17-Alkylated Prodrugs of Opioids | OPRM1, OPRD1, OPRL1 | SMN1; SMN2 1877/4885TP53 4312/4885HBB 1217/4885 |
| US-20100267614-A1 | Prodrugs of Peripheral Phenolic Opioid Antagonists | OPRM1, OPRK1, OPRL1 | SMN1; SMN2 2579/4885TP53 4815/4885HBB 1759/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.