Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 14/20 | 0.74 |
| ▸ | HSD17B10 | Q99714 | 10/20 | 0.74 |
| ▸ | MEN1 | O00255 | 6/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.74 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.74 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.74 |
| ▸ | HPGD | P15428 | 6/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | PRKCZ | Q05513 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 10/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.60 |
| ▸ | TSHR | P16473 | 3/20 | 0.60 |
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | PKM | P14618 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | CFTR | P13569 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | CASP7 | P55210 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL688353 | 0.85 | ALDH1A1 (1.00) | ALDH1A1HSD17B10MEN1KMT2AALOX15 | |
| SCHEMBL688523 | 0.77 | PRKCZ (1.00) | ALDH1A1HSD17B10MEN1KMT2AHPGD | |
| SCHEMBL5322468 | 0.74 | MAPT (0.73) | ALDH1A1HSD17B10MEN1KMT2ATDP1 | |
| SCHEMBL8198873 | 0.73 | ALDH1A1 (0.68) | ALDH1A1HSD17B10MEN1KMT2AALOX15 | |
| SCHEMBL5322173 | 0.73 | ALDH1A1 (1.00) | ALDH1A1HSD17B10MEN1KMT2AHPGD | |
| SCHEMBL8200826 | 0.72 | ALDH1A1 (0.50) | ALDH1A1HSD17B10MEN1KMT2AALOX15 | |
| SCHEMBL8288639 | 0.71 | ALDH1A1 (0.76) | ALDH1A1HSD17B10MEN1KMT2AHPGD | |
| SCHEMBL2182710 | 0.71 | PRKCZ (1.00) | ALDH1A1HSD17B10MEN1KMT2AALOX15 | |
| SCHEMBL3995640 | 0.71 | ALDH1A1 (0.76) | ALDH1A1HSD17B10MEN1KMT2AHPGD | |
| SCHEMBL3932115 | 0.71 | ALDH1A1 (0.76) | ALDH1A1HSD17B10MEN1KMT2AALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8765757-B2 | 3-heterocyclic substituted indole derivatives and methods of use thereof | MERCK SHARP & DOHME CORP. (US) | 2014-07-01 | — | — | US | disclosed |
| EP-2222660-B1 | 3-HETEROCYCLIC SUBSTITUTED INDOLE DERIVATIVES AND METHODS OF USE THEREOF | MERCK SHARP & DOHME (US) | 2014-03-26 | — | — | EP | disclosed |
| US-20110165118-A1 | 3-HETEROCYCLIC SUBSTITUTED INDOLE DERIVATIVES AND METHODS OF USE THEREOF | SCHERING CORPORATION | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110165118-A1 | 3-HETEROCYCLIC SUBSTITUTED INDOLE DERIVATIVES AND METHODS OF USE THEREOF | IDO1, IDO2, HTR3C | ALDH1A1 1668/4885HSD17B10 1328/4885MEN1 1468/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.