Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 2/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
| ▸ | CTSG | P08311 | 1/20 | 0.33 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.33 |
| ▸ | CMA1 | P23946 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16869153 | 0.98 | DGAT1 (0.34) | DGAT1PRSS1CTSGCTRB1CMA1 | |
| SCHEMBL16869115 | 0.86 | ALDH1A1 (0.44) | DGAT1TSHRALDH1A1 | |
| SCHEMBL13391772 | 0.85 | ALDH1A1 (0.43) | DGAT1TSHRTHRBALDH1A1 | |
| SCHEMBL17574066 | 0.84 | DGAT1 (0.42) | DGAT1PRSS1CTSGCTRB1CMA1 | |
| SCHEMBL10682128 | 0.83 | DGAT1 (0.35) | DGAT1TSHRTHRBALDH1A1 | |
| SCHEMBL355529 | 0.83 | TSHR (0.38) | DGAT1TSHRTHRBALDH1A1 | |
| SCHEMBL16163882 | 0.82 | DGAT1 (0.41) | DGAT1 | |
| SCHEMBL1012154 | 0.81 | DGAT1 (0.41) | DGAT1PRSS1CTSGCTRB1CMA1 | |
| SCHEMBL356764 | 0.81 | DGAT1 (0.34) | DGAT1 | |
| SCHEMBL27265814 | 0.81 | DGAT1 (0.34) | DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105705508-B | Acyclonucleosides phosphoric acid ester derivant and preparation method thereof and application medically | 四川海思科制药有限公司 | 2017-09-01 | — | — | CN | disclosed |
| CN-105705508-A | Acyclic nucleoside phosphonate derivative and preparation method and use thereof in medical science | 四川海思科制药有限公司 | 2016-06-22 | — | — | CN | disclosed |
| US-20160046576-A1 | NOVEL PYRROLE DERIVATIVES | UNIV LEICESTER (GB) | 2016-02-18 | — | — | US | disclosed |
| US-20160046576-A1 | NOVEL PYRROLE DERIVATIVES | UNIV LEICESTER (GB) | 2016-02-18 | — | — | US | disclosed |
| US-9221756-B2 | Pyrrole derivatives | UNIVERSITY OF LEICESTER (GB) | 2015-12-29 | — | — | US | disclosed |
| US-9221756-B2 | Pyrrole derivatives | UNIVERSITY OF LEICESTER (GB) | 2015-12-29 | — | — | US | disclosed |
| WO-2015096697-A1 | ACYCLIC NUCLEOSIDE PHOSPHONATE DERIVATIVE AND PREPARATION METHOD AND USE THEREOF IN MEDICAL SCIENCE | 四川海思科制药有限公司 | 2015-07-02 | — | — | WO | disclosed |
| US-20140309193-A1 | NOVEL PYRROLE DERIVATIVES | UNIVERSITY OF LEICESTER (GB) | 2014-10-16 | — | — | US | disclosed |
| US-20140309193-A1 | NOVEL PYRROLE DERIVATIVES | UNIVERSITY OF LEICESTER (GB) | 2014-10-16 | — | — | US | disclosed |
| EP-2788324-A2 | NOVEL PYRROLE DERIVATIVES | University Of Leicester (GB) | 2014-10-15 | — | — | EP | disclosed |
| WO-2013083975-A2 | NOVEL PYRROLE DERIVATIVES | UNIVERSITY OF LEICESTER (GB) | 2013-06-13 | — | — | WO | disclosed |
| US-8372874-B2 | Compounds which selectively modulate the CB2 receptor | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-02-12 | — | — | US | disclosed |
| US-8372874-B2 | Compounds which selectively modulate the CB2 receptor | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-02-12 | — | — | US | disclosed |
| US-8372874-B2 | Compounds which selectively modulate the CB2 receptor | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-02-12 | — | — | US | disclosed |
| EP-2342199-A2 | COMPOUNDS WHICH SELECTIVELY MODULATE THE CB2 RECEPTOR | Boehringer Ingelheim International GmbH (DE) | 2011-07-13 | — | — | EP | disclosed |
| WO-2010036631-A2 | COMPOUNDS WHICH SELECTIVELY MODULATE THE CB2 RECEPTOR | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-04-01 | — | — | WO | disclosed |
| WO-2010036631-A2 | COMPOUNDS WHICH SELECTIVELY MODULATE THE CB2 RECEPTOR | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-04-01 | — | — | WO | disclosed |
| US-20100076029-A1 | Compounds Which Selectively Modulate The CB2 Receptor | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-03-25 | — | — | US | disclosed |
| US-20100076029-A1 | Compounds Which Selectively Modulate The CB2 Receptor | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-03-25 | — | — | US | disclosed |
| US-20100076029-A1 | Compounds Which Selectively Modulate The CB2 Receptor | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100076029-A1 | Compounds Which Selectively Modulate The CB2 Receptor | CNR2, CNR1, OPRL1 | DGAT1 981/4885PRSS1 3268/4885CTSG 1533/4885 |
| US-20160046576-A1 | NOVEL PYRROLE DERIVATIVES | PYCR1, ARG1, PNISR | DGAT1 4704/4885PRSS1 560/4885CTSG 3669/4885 |
| US-20140309193-A1 | NOVEL PYRROLE DERIVATIVES | PYCR1, ARG1, PNISR | DGAT1 4704/4885PRSS1 560/4885CTSG 3669/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.