Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 1/20 | 0.42 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | IDH1 | O75874 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19308079 | 0.84 | TRPV4 (0.35) | MDM2MAPTTRPV4 | |
| SCHEMBL18948558 | 0.80 | GSTO1 (0.46) | MDM2HTTMEN1KMT2AALDH1A1 | |
| SCHEMBL19157910 | 0.79 | ACLY (0.40) | MDM2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL20083954 | 0.77 | MAPT (0.41) | HTTMAPTTRPV4SMN1; SMN2PKM | |
| SCHEMBL20647783 | 0.75 | MAPT (0.39) | HTTMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL20647677 | 0.75 | MAPT (0.46) | KMT2AALDH1A1MAPTTSHRSMN1; SMN2 | |
| SCHEMBL19841963 | 0.74 | MAPT (0.48) | HTTALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL20647771 | 0.74 | ENPP2 (0.45) | HTTMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL20647758 | 0.74 | MAPT (0.39) | MDM2HTTMAPTSMN1; SMN2 | |
| SCHEMBL20647781 | 0.74 | CYP3A4 (0.42) | HTTMAPTSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3312160-B1 | HEPATITIS B ANTIVIRAL AGENTS | NOVIRA THERAPEUTICS INC (US) | 2020-03-18 | — | — | EP | disclosed |