Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 6/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21852723 | 0.89 | ALDH1A1 (0.50) | ALDH1A1MAPK1MAPTKDM4EGAA | |
| SCHEMBL21852720 | 0.78 | L3MBTL1 (0.64) | ALDH1A1MAPK1MAPTKDM4EGAA | |
| SCHEMBL3455711 | 0.78 | ALDH1A1 (0.75) | ALDH1A1MAPTKDM4EGAATSHR | |
| SCHEMBL8325259 | 0.77 | L3MBTL1 (0.68) | ALDH1A1MAPK1MAPTKDM4EGAA | |
| SCHEMBL15266902 | 0.76 | L3MBTL1 (0.63) | ALDH1A1MAPK1MAPTKDM4EGAA | |
| SCHEMBL4582989 | 0.72 | L3MBTL1 (0.53) | ALDH1A1MAPK1MAPTGAAL3MBTL1 | |
| SCHEMBL27976453 | 0.71 | AKR1C3 (0.85) | ALDH1A1MAPK1MAPTKDM4EGAA | |
| SCHEMBL632352 | 0.70 | L3MBTL1 (0.73) | ALDH1A1MAPK1MAPTKDM4EGAA | |
| SCHEMBL4182066 | 0.70 | L3MBTL1 (0.73) | ALDH1A1MAPK1MAPTKDM4EGAA | |
| SCHEMBL2767534 | 0.70 | DRD2 (0.81) | ALDH1A1MAPK1MAPTKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11324731-B2 | TXNIP-TRX complex inhibitors and methods of using the same | CITY OF HOPE (US) | 2022-05-10 | — | — | US | disclosed |
| US-20200085800-A1 | TXNIP-TRX COMPLEX INHIBITORS AND METHODS OF USING THE SAME | CITY OF HOPE | 2020-03-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11324731-B2 | TXNIP-TRX complex inhibitors and methods of using the same | TXN, TXN2, TXNRD3 | ALDH1A1 3479/4885MAPK1 2728/4885MAPT 2647/4885 |
| US-20200085800-A1 | TXNIP-TRX COMPLEX INHIBITORS AND METHODS OF USING THE SAME | TXN, TXN2, TXNRD3 | ALDH1A1 3479/4885MAPK1 2728/4885MAPT 2647/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.