SCHEMBL2185973

SCHEMBL2185973

O=Nc1cc(Br)ccc1O

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 2/20 0.50
CASP1 P29466 3/20 0.48
HPGD P15428 2/20 0.48
CES2 O00748 1/20 0.48
GALR3 O60755 1/20 0.48
CYP1A2 P05177 1/20 0.48
CYP2C9 P11712 1/20 0.48
CYP2C19 P33261 1/20 0.48
ERN1 O75460 2/20 0.47
KMT2A Q03164 5/20 0.42
GAA P10253 5/20 0.42
MAPT P10636 5/20 0.42
KDM4E B2RXH2 4/20 0.42
MEN1 O00255 1/20 0.42
ALDH1A1 P00352 1/20 0.42
PKM P14618 1/20 0.42
GSTA1 P08263 1/20 0.41
LMNA P02545 3/20 0.41
ALOX12 P18054 1/20 0.41
BCL2 P10415 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28644250 0.82 ALOX15 (0.44) ALOX15CASP1HPGDCES2GALR3
SCHEMBL3070179 0.76 ALDH1A1 (0.45) ALOX15CASP1HPGDCES2CYP1A2
SCHEMBL3650552 0.76 HSP90AA1 (0.46) ALOX15CASP1HPGDCES2GALR3
SCHEMBL12228262 0.74 MAPT (0.40) ALOX15HPGDCYP1A2CYP2C19KMT2A
SCHEMBL8722404 0.73 CASP3 (0.53) ALOX15CASP1HPGDCYP2C9CYP2C19
SCHEMBL10091983 0.73 DGAT1 (0.39) ALOX15CASP1HPGDCES2GALR3
SCHEMBL2608523 0.73 ALDH1A1 (0.40) HPGDCYP1A2ERN1KMT2AMAPT
SCHEMBL1031711 0.73 MAPT (0.58) ALOX15HPGDKMT2AGAAMAPT
SCHEMBL13607302 0.73 CA3 (0.44) HPGDCES2KMT2AMAPTKDM4E
SCHEMBL12963249 0.73 KDM4E (0.45) ALOX15KMT2AGAAMAPTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113651788-A 3-amine alkyl chromone compound and preparation method thereof 东华理工大学 2021-11-16 CN disclosed
EP-3229844-B1 ANTIBODY DRUG CONJUGATES WITH CELL PERMEABLE BCL-XL INHIBITORS ABBVIE INC (US) 2020-03-04 EP disclosed
US-9669032-B2 Enhanced treatment regimens using mTOR inhibitors INTELLIKINE LLC (US) 2017-06-06 US disclosed
CN-102741745-B Photochromic material KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION (KR) 2015-08-19 CN disclosed
CN-102652282-B Photochromic material UNIV KOREA RES & BUS FOUND 2014-09-17 CN disclosed
US-8801976-B2 Photochromic material KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION (KR) 2014-08-12 US disclosed
US-8801976-B2 Photochromic material KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION (KR) 2014-08-12 US disclosed
US-8801976-B2 Photochromic material KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION (KR) 2014-08-12 US disclosed
US-20140191168-A1 PHOTOCHROMIC MATERIAL KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION (KR) 2014-07-10 US disclosed
US-20140191168-A1 PHOTOCHROMIC MATERIAL KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION (KR) 2014-07-10 US disclosed
WO-2011102599-A1 PHOTOCHROMIC MATERIAL KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION (KR) 2011-08-25 WO disclosed
US-20110198546-A1 PHOTOCHROMIC MATERIAL KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION (KR) 2011-08-18 US disclosed
US-20110198546-A1 PHOTOCHROMIC MATERIAL KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION (KR) 2011-08-18 US disclosed
US-20110198546-A1 PHOTOCHROMIC MATERIAL KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION (KR) 2011-08-18 US disclosed
WO-2011096643-A1 PHOTOCHROMIC MATERIAL KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION (KR) 2011-08-11 WO disclosed
US-20110163282-A1 PHOTOCHROMIC MATERIAL KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION (KR) 2011-07-07 US disclosed
US-20110163282-A1 PHOTOCHROMIC MATERIAL KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION (KR) 2011-07-07 US disclosed
US-20110163282-A1 PHOTOCHROMIC MATERIAL KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION (KR) 2011-07-07 US disclosed
US-5789138-A Optical recording medium and method of producing the same RICOH COMPANY, LTD. (JP) 1998-08-04 US disclosed
EP-0189773-A2 Process for preparing composite articles from rubber and pourable polyurethane elastomers RHEIN-CHEMIE RHEINAU GmbH (DE) 1986-08-06 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110198546-A1 PHOTOCHROMIC MATERIAL PPOX, RAD51, DCLRE1A ALOX15 2978/4885CASP1 4035/4885HPGD 206/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.