Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CASR | P41180 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2187578 | 0.85 | TDP1 (0.46) | SMN1; SMN2NPC1RAB9AMAPK1GAA | |
| SCHEMBL2187668 | 0.81 | KMT2A (0.48) | SMN1; SMN2NPC1RAB9AMAPK1GAA | |
| SCHEMBL2187530 | 0.75 | SMN1; SMN2 (0.47) | SMN1; SMN2NPC1RAB9ATDP1CYP3A4 | |
| SCHEMBL2186531 | 0.72 | NFKB1 (0.41) | SMN1; SMN2NPC1RAB9AGAATDP1 | |
| SCHEMBL2187394 | 0.71 | IRAK4 (0.49) | L3MBTL1 | |
| Hydrochloric Acid SCHEMBL5008548 | 0.68 | L3MBTL1 (0.54) | SMN1; SMN2NPC1RAB9ALMNAL3MBTL1 | |
| SCHEMBL16767096 | 0.68 | CSNK1E (0.53) | L3MBTL1 | |
| SCHEMBL18619678 | 0.67 | LMNA (0.55) | LMNAL3MBTL1 | |
| SCHEMBL2187574 | 0.67 | GAA (0.44) | SMN1; SMN2NPC1RAB9AMAPK1GAA | |
| SCHEMBL420357 | 0.65 | AR (0.54) | SMN1; SMN2NPC1RAB9ALMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2343293-A1 | NOVEL PIPERIDIN-4-YL-THIAZOLE-CARBOXAMIDE ANALOGUES AS INHIBITORS OF T-CELL PROLIFERATION AND USES THEREOF | 4SC AG (DE) | 2011-07-13 | — | — | EP | disclosed |